All news from Pathology & Microbiology

Pathogenesis

New Mechanism: By Bacteria To Evade Antibiotics

Antibiotics survival mechanism; researchers have discovered an unexpected mechanism that allows bacteria to defend themselves against antibiotics; a surprise finding that could lead to retooled drugs to treat infectious diseases. When under attack by antibiotics; bacteria were found to modulate magnesium ion uptake in order to stabilize their ribosomes; the fundamental molecular machines of life…

Fighting Infection

'Iron Man' of Immune Cells: Helps T Cells Fight Infection

The immune system’s killer T cells are crucial in fighting viral infections. A fraction of them, called ‘memory cells’; live on once infection is controlled in order to fight re-infection by the same virus. They are of great interest as the basis of T cell-based vaccination and immunotherapies. Now, a study by Monash Biomedicine Discovery…

Infection

Neonatal Herpes Simplex Virus: Treated With Acyclovir

Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. Both HSV-1 (which produces most cold sores) and HSV-2 (which produces most genital herpes)…

Tropical medicine

Triazavirin Defeats Tick-borne Encephalitis

The drug triazavirin, developed by the researchers of the Ural Branch of the Russian Academy of Sciences; and the Institute of Chemical Engineering of Ural Federal University; has proved to be an effective remedy against tick-borne viral encephalitis (TBE). Clinical trials conducted by Krasnoyarsk State Medical University led to this conclusion. The results are published…

Infection

What Makes Helicobacter Adaptable? Infection Biology Explains

The bacterial pathogen Helicobacter pylori owes its worldwide distribution to its genetic adaptability. Ludwig-Maximilians-Universitaet (LMU) Munich microbiologists have identified an enzyme; that plays a vital role in the flexible control of global gene expression in the species. The cosmopolitan bacterium Helicobacter pylori; which colonizes the mammalian gastrointestinal system; is responsible for one of the most common…

Pathognesis

'Mutation hotspot': Common Fungus In Different Host Environments

The fungus Candida albicans; found in the gastrointestinal tract of about half of healthy adults with little if any effect; yet it also causes an oft-fatal blood infection among patients with compromised immune systems, including those with HIV/AIDS.  The research found that patient samples of the fungus frequently lack one copy of a gene; that…

Pathogenesis

Fungus: Cripple The Immune System

It is everywhere — and it is extremely dangerous for people with a weakened immune system. The fungus Aspergillus fumigatus occurs virtually everywhere on Earth, as a dark grey, wrinkled cushion on damp walls or in microscopically small spores that blow through the air and cling to wallpaper, mattresses and floors. Healthy people usually have no problem…

Dengue

Dengue Virus Following Zika virus Infection: Severe Outcomes

Zika virus (ZIKV) has association with birth defects and pregnancy loss after maternal infection. Because dengue virus (DENV) and ZIKV co-circulate, understanding the role of antibody-dependent enhancement in the context of pregnancy is critical. Here, we showed that the presence of DENV-specific antibodies in ZIKV-infected pregnant mice significantly increased placental damage, fetal growth restriction, and…

Infection

Reservoir Of Bacteria: Sink Harbor Dangerous Organisms

Sinks situated next to patient toilets in hospital rooms may be reservoirs for Klebsiella pneumoniae carbapenemase (KPC), increasing the risk of dangerous germ transmission, according to new research published in the American Journal of Infection Control (AJIC), the journal of the Association for Professionals in Infection Control and Epidemiology. Surgical site infections The study found a high…

Pathogenesis

Tick-borne Infections: People Tolerate More Easily

Tomsk scientists have conducted a study to identify the characteristics of the course of tick-borne infections and their consequences among residents of several Siberian regions. The findings suggest that the indigenous peoples of the North, and the sixth- and eighth-generation descendants of Siberians more easily tolerate, and recover more quickly from; infection with tick-borne encephalitis (TBE),…

Bacterial infection

Managing Acinetobacter Baumannii Infections

Acinetobacter baumannii is a gram-negative aerobic bacillus; that primarily causes hospital-acquired infections affecting specially to debilitated patients with prolonged hospitalization and with long-term exposition to antimicrobials. Until now, the ICUs have been considered as the epicenters of A. baumannii infections. Nevertheless, spread to general wards and long-term care facilities have also been shown to play an important role.…

Pathogenesis

Immune Master Regulator And Parasite Infection

A new study has identified the master regulator that maintains a healthy gut and limits damage by parasitic whipworms. Researchers from the Wellcome Sanger Institute and collaborators have revealed that the interleukin 10 receptor (IL-10R) is critical to prevent uncontrolled whipworm infection; in mice and a damaging immune response in the gut. The study, published…