Flaviviral infections, a family of viral infections transmitted by mosquitoes and ticks; are major health concerns as they spread rapidly and lack licensing treatments. Implications for the prevention and treatment of infectious diseases causing by flaviviral infections such as dengue fever; congenital Zika syndrome and yellow fever.
Flaviviral infections result in a wide spectrum of clinical outcomes; ranging from asymptomatic infection to severe disease. Study finding that immune cells undergoing stress; and an altering metabolism are the reasons why some individuals becoming sick from viral infections while others do not; when exposing to the same virus.
Development of viral infections
Most viral infections result in a range of outcomes even when individuals are infected with the same amount of virus in their blood. For example, up to two-thirds of all dengue virus infections result in no symptoms, while the remaining one-third go on to develop dengue fever and even fewer progress to severe dengue.
Understanding why this happens could lead to new ways of preventing disease and reduce the burden of some viral diseases. But in some individuals do not get sick despite being infecting with the same virus, while others develop symptoms and infections.
Prevention and treatment methods
Understanding the molecular events; that lead to development of symptoms could lead to new prevention and treatment methods for infectious diseases worldwide; The team conducted two clinical trials involving more than 100 healthy adults using the yellow fever vaccine; one of the most effective vaccines in the world with an excellent safety profile.
The study findings show that increased levels of stress and altered metabolism of an individual’s immune cells are factors that make one prone to developing symptoms during an infection. Correspondingly; this tells us that immune cells and metabolic pathways could be useful targets to develop treatments for yellow fever or other flaviviral infections.