The study showing disease causing bacteria compete with human hosts; for key micronutrient. As microbiologist showing that disease causing bacteria compete with their human hosts for a key micronutrient. All multi celled organisms rely on single-celled ones, bacteria, to synthesize queuine. The human gut naturally has these queuine manufacturers, or they enter the body through the plant and animal sources we consume.
Humans are able to recover the queuine we need through what are known as salvage enzymes; It utilizing computer driving data mining to investigate queuine metabolism in two pathogenic, or disease-causing, bacteria; Chlamydia trachomatis, commonly known as the sexually transmitted disease chlamydia, and Clostridioides difficile, sometimes shortened to C. diff; that causes diarrhea and other intestinal issues and involves abnormal gut bacteria levels.
Disease causing bacteria
The presence of queuine salvage enzymes in these bacteria, which makes this competition possible, were a brand-new discovery; The bacteria is essentially behaving like humans by not making its own queuine, instead stealing it through an enzymatic process that had not previously been described; Next, I want to look at all of the bacteria of the microbiota and looking at all of the exchanges that occur. We want to try and model the interaction between bacteria in the gut and the host.
At this time, queuine is both difficult and expensive to synthesize in a lab. But it is not available in any sort of commercial supplements; Queuosine (Q) is a complex tRNA modification widespread in eukaryotes and bacteria that contributes to the efficiency and accuracy of protein synthesis. But eukaryotes are not capable of Q synthesis and rely on salvage of the queuine base (q) as a Q precursor.
Capable of Q synthesis
Queuosine (Q) is a tRNA modification finding in eukaryotes and bacteria; that plays an important role in translational efficiency and accuracy. Queuine (q), but the Q nucleobase, is increasingly appreciated as an important micronutrient that contributes to human health. But the study describe here that q salvage pathways exist in bacteria, including many pathogens and host-associated organisms; suggesting a direct competition for the q precursor in the human gut microbiome.
However, the study also show how a rational use of comparative genomics; can lead to the discovery of novel types of enzymatic reactions, illustrated by the discovery of the queuine lyase enzyme. Queuine is important in these pathogens, but it must be important because the queuine salvage enzymes are there, too. Scientists didn’t previously think that bacteria would compete with a human host for this micronutrient.