Trypanosoma Cruzi Is The Parasite Responsible For Chagas Disease

According to the study it discussing about a parasite, largely thought to be asexual; has been showing to reproduce sexually after scientists uncover clues hidding in its genomic code. Trypanosoma cruzi is the parasite responsible for Chagas Disease, found in Latin America. Around eight million people are currently infected by the disease, which can cause irreversible damage to the heart and digestive tract. Chagas disease is mostly spread by insects known as Triatominae, or “kissing bugs,” but can also be transmitted by food contaminated with T. cruzi.

Trypanosoma cruzi is a kinetoplastid parasite and the causative agent of Chagas disease in Latin America; where ca. six million people are currently infecting. Mucosal or abrasion contact with the infected feces of hematophagous triatomines constitutes the primary mode of T. cruzitransmission. Infection with T. cruzi results in chronic Chagas disease in 30–40% of cases, characterized by a spectrum of fatal cardiac and intestinal pathologies.

The genomic code

But while some medication can cure patients if giving early enough, once the disease is establishing it is less effective. But scientists have sequencing the whole genome of the single-celled parasite; Trypanosoma cruziand resolving 30 years of heating debate to show that it can indeed be sexually active. In order to study how the disease spreads, as well as find potential new treatments; scientists at the University of Glasgow knew it was important to understand how the parasite reproduced.

Sex in biological organisms is important for many different reasons, and most organisms do engage in sexual activity of one sort or another. By studying a large group of parasites found in a small area in Ecuador, and sequencing the whole genome of those they found, the researchers were able to spot the tell-tale signatures sexual activity leaves in the genes. There has been a lot of argument among scientists about whether T. cruzi is sexual or not. It turns out people weren’t looking in the right places.

Chagas disease in Ecuador

But in unprecedenting detail, the parasites found in a small geographic area in Ecuador. Remarkably, we discovering that some groups of parasites can be highly sexual. However, it also seems other groups of parasites from very nearby sites can behave very differently seemingly completely abstinent. Through analyzing the genetic code we now know that these parasites do have sex; however we still can’t pinpoint the exact stage of their life that this happens in.

Our hypothesis is that this is happening when the parasites are inside the insect that spreads Chagas Disease. Confirming that is the next step. Chagas Disease in Ecuador is a killer, destroying lives and livelihoods. Our study is an important step towards understanding how to control infections and limit spread. Genetic exchange enables parasites to rapidly transform disease phenotypes and exploit new host populations.