Mom's voice

For most children, the sound of their mother’s voice triggers brain activity patterns distinct from those triggered by an unfamiliar voice. But the unique brain response to mom’s voice is greatly diminished in children with autism; according to a new study from the Stanford University School of Medicine. “Kids with autism often tune out from the voices around them; they have not known why.
The results suggest that the brains of children with autism are not wired to easily tune into mom’s voice. The study also found that the degree of social communication impairment in individual children with autism correlated with the degree of abnormality in their brain responses to their mother’s voice. “This study is giving us a handle on circuits and vocal stimuli that they have to make more engaging for a child with autism “They now have a template for targeting specific neural circuits with cognitive therapies.”

An important social cue

Mom’s voice is an important social cue for most children. For instance, tiny babies recognize and are soothed by their mother’s voice; while young teenagers are more comfort by words of reassurance spoken by their mothers than the same words sent by their mothers via text message, prior research has shown. The response to mom’s voice has a distinct brain-activation signature in children without autism.
Autism is a developmental disorder that affects 1 in 59 children. It is by social and communication difficulties; restricted interests and repetitive behaviors. The disorder exists on a spectrum; with some children more impaired than others. The new study included 42 children ages 7 to 12. Half had autism; the other half did not. The children had their brains scanned using functional magnetic resonance imaging while listening to three different recorded sounds: their mother’s voice; the voices of unfamiliar women; and nonvocal environmental sounds.

Comprehension regions in the brain

In the voice recordings, the women said nonsense words to avoid activating language comprehension regions in the brain. The researchers compared patterns of brain activation and brain network; connectivity between the two groups of children. They also asked the children to identify whether each brief (956-millisecond); voice recording they heard came from their mother or an unfamiliar woman.

The brain response to unfamiliar voices; when compared with the response to environmental sounds, fairly similar in children with and without autism; although those with autism less activity in one area of the auditory association cortex. When comparing the brain response to mom’s voice versus unfamiliar voices, children without autism had many more brain areas activated: Mom’s voice preferentially lit up part of the hippocampus; a learning and memory region, as well as face-processing regions.

Brain-connectivity patterns measured in a network that included auditory-processing regions, reward-processing regions and regions that determine the importance, or salience, of incoming information; also distinguished children with autism from children without autism. The network impairments in individual children with autism also linked to their individual level of social communication impairment.

Really striking relationship

There is this really striking relationship between the strength of activity and connectivity in reward and salience regions during voice processing and children’s social communication activity. This suggests that brain responses to mom’s voice are a key element for building social communication ability. The findings support the social motivation theory of autism, which suggests that social interaction is intrinsically less engaging for children with the disorder than those without it.
Many current autism therapies involve motivating children to engage in specific types of social interaction. It would be interesting to conduct future studies to see whether these therapies change the brain characteristics uncovered in this study, the researchers said. “Mom’s voice is the primal cue for social and language communication and learning,” Menon said. “There is an underlying biological difference in the brain circuitry in autism, and this is a precision-learning signal we can target.”