All news from Ophthalmology

Potential New Gene Therapy for Blinding Disease, Study Reports

The last year has seen milestones in the gene therapy field, with FDA approvals to treat cancer and an inherited blinding disorder. The researchers, from Penn's School of Veterinary Medicine and Perelman School of Medicine, in collaboration with University of Florida scientists, developed a therapy that effectively eliminates the abnormal copy of rhodopsin, a light-sensing molecule, and then restores it with a healthy copy of the protein??

Vasoactive Intestinal Peptide Promotes Corneal Allograft Survival

A study showed that injection of neuropeptide vasoactive intestinal peptide (VIP) directly into the eye of mice enhanced corneal graft survival. VIP produced other benefits, including acceleration of endothelial wound closure, protection of corneal endothelial cells (CEnCs), and improved corneal graft clarity.

If proven successful in clinical studies, this novel approach may help alleviate visual loss in many patients with corneal disease. The study was published in the American Journal of PathologyThe successful outcome of corneal transplantation mainly relies on the density and function of CEnCs, which keep the graft transparent.

To improve the outcomes of corneal transplantation, various strategies have been employed to prevent immune-mediated graft rejection or enhance survival and function of CEnCs. However, an effective method has remained elusive so far.