Retinal microvascular abnormalities are identified in cognitively healthy individuals who have biomarkers positive for Alzheimer's disease (AD), according to a study published online Aug. 23 in JAMA Ophthalmology
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Scientists at Scripps Research have developed a urine diagnostic to detect the parasitic worms that cause river blindness, also called onchocerciasis, a tropical disease that afflicts 18 to 120 million people worldwide
The last year has seen milestones in the gene therapy field, with FDA approvals to treat cancer and an inherited blinding disorder. The researchers, from Penn's School of Veterinary Medicine and Perelman School of Medicine, in collaboration with University of Florida scientists, developed a therapy that effectively eliminates the abnormal copy of rhodopsin, a light-sensing molecule, and then restores it with a healthy copy of the protein??
A 59-year-old man was in the shower, wiping his eyes with a towel when he heard a popping sound and felt pain shoot through his left eye. His cornea had developed a severe ulcer and ruptured, tearing a hole in his eye
New findings from a team led by University of Pennsylvania vision scientists, who have in the past taken gene therapies into clinical trials, are proving successful, this time treating a form of retinitis pigmentosa, a disease that progressively robs people of their night and peripheral vision before blindness develops
A new University of Liverpool study, published in Wiley Brain and Behaviour, examines the factors that influence how a person adapts to visual field loss following stroke
Researchers funded by the National Eye Institute (NEI) have reversed congenital blindness in mice by changing supportive cells in the retina called Müller glia into rod photoreceptors
A research team from Massachusetts Eye and Ear and the Massachusetts Institute of Technology have shown that immune cells in the eye that developed in response to early exposure to bacteria are a key contributor to progressive vision loss from glaucoma, the second leading cause of irreversible blindness in the world
As children spend more time tethered to screens, there is increasing concern about potential harm to their visual development. Ophthalmologists—physicians who specialize in medical and surgical eye care—are seeing a marked increase in children with dry eye and eye strain from too much screen time
A study showed that injection of neuropeptide vasoactive intestinal peptide (VIP) directly into the eye of mice enhanced corneal graft survival. VIP produced other benefits, including acceleration of endothelial wound closure, protection of corneal endothelial cells (CEnCs), and improved corneal graft clarity.
If proven successful in clinical studies, this novel approach may help alleviate visual loss in many patients with corneal disease. The study was published in the American Journal of Pathology. The successful outcome of corneal transplantation mainly relies on the density and function of CEnCs, which keep the graft transparent.
To improve the outcomes of corneal transplantation, various strategies have been employed to prevent immune-mediated graft rejection or enhance survival and function of CEnCs. However, an effective method has remained elusive so far.