Endometriosis is a medical condition in women in which endometrial cells are deposit in areas outside the uterine cavity. The uterine cavity is line by endometrial cells, which are under the influence of female hormones. Therefore Endometrial cells deposited in areas outside the uterus (endometriosis) continue to be influence by these hormonal changes and respond similarly as do those cells found inside the uterus. Symptoms often exacerbate in time with the menstrual cycle.
Influence of female hormones
Endometriosis is typically see during the reproductive years; it has been estimate that it occurs in roughly 5% to 10% of women. Symptoms depend on the site of implantation. Its main but not universal symptom is pelvic pain in various manifestations. Endometriosis is a common finding in women with infertility.Endometriosis is a disease that affects 10 to 15% of all reproductive-aged women.
Although no cure has been find, researchers seek to determine why some women develop endometriosis and in order to develop effective treatments. Researchers from Tartu have completed a study toward explaining the causes of endometriosis. Endometriosis is a disorder in which tissue that lines the inside of the uterus, the endometrium, grows and develops lesions outside the uterine cavity. Inflammation causes chronic pelvic pain, painful intercourse and pain with urination and bowel movements, and often causes infertility.
Causes chronic pelvic pain
According to researcher Merli Saare, nobody actually knows how many women suffer from the disease, because it is not easy to diagnose. So far, there is no method for identifying endometriosis from a blood sample. “Today, the disease is mainly diagnose surgically. In general, patients have to undergo a laparoscopic procedure in which lesions are surgically remove from the abdominal cavity. Small pieces of this tissue are taken for histological analysis that helps to confirm the diagnosis,” explained Saare.
Surgical removal of lesions relieves symptoms, but does not cure the disease, which tends to recur. In addition to the fact that there is no effective treatment for endometriosis, researchers still do not know exactly which factors support the development of the disease or why some women have it and others do not. The causes of endometriosis are studied by analysing the uterine mucosa and the tissue that grows in the abdominal cavity.
Menstrual cycle factors
Like any other endometrium-relate diseases, menstrual cycle factors have to be consider while studying endometriosis. Women usually inform doctors of the day of their menstrual cycle when they go to surgery. However, this may not be accurate enough for determining the exact phase of the menstrual cycle, as Saare and her colleagues report in their research paper, published in the journal Biology of Reproduction.