Nuclear medicine

The study find that PET/CT -based diagnostic strategy adds decisive new information compare to conventional imaging in the evaluation of salivary gland tumours and the detection of cervical lymph node metastases; distant metastases; and synchronous cancer in patients with salivary gland carcinoma. Therefore Salivary gland carcinoma is an uncommon disease and represents only 3–5% of all head and neck cancers.

Cervical lymph node

Furthermore, primary salivary gland carcinoma is a heterogeneous group of cancers with different biological behaviour, malignant potential and prognosis. The wide variety of histological subtypes combine with relatively few patients in all ages complicates studies on epidemiology, diagnostics; treatment, and prognosis. Because Histological grade and tumour stage are important prognostic factors and decisive in the treatment planning.

Preoperative diagnostic imaging is necessary for tumour staging and enables appropriate extent of surgery and adjuvant treatment. Conventional imaging of the salivary glands consists of compute tomography (CT); magnetic resonance imaging (MRI), and chest X-ray (CXR); and neck ultrasonography (US). MRI and CXR have been apply prior to surgery in patients suspect of salivary gland carcinoma in Denmark since 2010. Utility of positron emission tomography (PET) ; in diagnosing salivary gland carcinomas is still controversial due to the high FDG-uptake in some benign salivary gland tumours .

Appropriate extent of surgery

In addition, normal physiologic uptake of FDG in salivary glands and the head and neck region is common and can hide tumours with relatively low FDG-uptake. Evaluation of PET/CT in salivary gland carcinoma is mainly base on retrospective series of relatively small groups of patients. In this study; a diagnostic imaging strategy with MRI/ CXR was prospectively compare to PET/CT in the evaluation of patients suspected of salivary gland carcinoma.

The aim is to investigate whether PET/CT adds decisive information to the diagnostic process and treatment planning in the initial staging of salivary gland carcinoma compare to conventional imaging strategy.There is reasoned suspicion of salivary gland carcinoma in 105 patients during the inclusion period. Fourteen are not include for the following reasons: nine are referr with suspected recurrence of salivary gland carcinoma, four did not undergo MRI; and one patient did not undergo surgery as demonstrated in the for chart in.

Salivary gland carcinoma

Thus, a total of 91 patients underwent MRI, CXR, PET/CT, and surgery. The study population consisted of 37 women (41%) and 54 men (59%), mean age 64 years (range 21–89). The most frequent primary tumour site was the parotid gland (54%) followed by the sub mandibular gland (29%), minor salivary glands (13%), and sublingual gland (4%). The 12 lesions in the minor salivary glands were anatomically located in the
oral cavity (92%) and in hypo pharynx (8%).