Study find that nanoparticles (NPs) using multi modal PET/MRI showed promising improvements in imaging capabilities. Using an MR Solutions; cryogen free, 3T scanner with a PET clip on the sequential images are find to be highly beneficial providing high spatial resolution, high sensitivity; high technical maturity with a low radiation dose. This pioneering agent highlights activity in the liver, spleen; lungs and kidneys before being gradually excrete from the body with no cytotoxicity observe.
High technical maturity
This is the first successful grafting of PEG and MANOTA chelator on prefunctionaliz iron oxide NPs synthesized under continuous hydrothermal conditions for bimodal PET/MRI imaging and shows the potential benefits. MR Solutions remains the only company with commercial installations of cryogen free MRI scanners from 3T to 7T.
All of these scanners can be fitted with either clip-on PET scanners for sequential scanning or insert into the bore to provide simultaneous scanning. The same PET clip-ons also be use on the recently launch range of MR’s CT scanners. Magnetic iron oxide NPs are nowadays use as potential multimodal imaging probes such as PET/MRI; MRI/ultrasound (US),(11) MRI/computed tomography (CT); or PET/near-infrared fluorescence/MRI. It can be highly beneficial to combine PET with MRI.
PET is highly sensitive and particularly well suited for molecular imaging. The simultaneous use of MRI and PET imaging leads to high spatial resolution, high sensitivity, high technical maturity; and low radiation doses. Thus; a radiolabeled MRI probe such as radiolabeled SPIONs may show great potential as an innovative, powerful, and promising tool to enhance the noninvasive diagnosis and treatment of patients.
MRI and PET imaging
Superpara magnetic iron oxide nanoparticles are develop as positron emission tomography (PET) and magnetic resonance imaging (MRI) bimodal imaging agents. These nanoparticles (NPs), with a specific nanoflower morphology, are first synthesize and simultaneously functionalized with 3,4-dihydroxy-l-phenylalanine (LDOPA) under continuous hydrothermal conditions. The resulting NPs exhibit a low hydrodynamic size of 90 ± 2 nm.
The functional groups of LDOPA (−NH2 and −COOH) were successfully use for the grafting of molecules of interest in a second step. The nanostructures were modified by poly(ethylene glycol) (PEG) and a new macrocyclic chelator MANOTA for further 64Cu radiolabeling for PET imaging.
Bimodal imaging agents
However, since each imaging modality possesses its own strengths and weaknesses, one single imaging technique is often not enough to evaluate the biological structure properties and information concerning a pathology or an injury with accuracy and in real time.
More particularly, MRI has low sensitivity and is not appropriate for molecular imaging. To overcome these drawbacks, multimodal imaging approaches, combining MRI with a complementary imaging technique, such as positron emission tomography (PET), are very interesting.