Epilepsy

Medicinal cannabis oil containing both cannabidiol (CBD) and a small amount of THC; (the drug that can cause intoxication) can reduce or end seizures in children with severe, drug-resistant epilepsy; a study by the University of Saskatchewan (USask) has found.

Children with severe epilepsy also experienced improvements in their quality of life; after taking low doses of the medicinal cannabis oil, according to research publish in Frontiers in Neurology. The study tested the effects of medicinal cannabis oil with 95 % CBD, a chemical which does not create a high; and five % THC; a substance which can be intoxicating in large enough doses.

Studying an evidence-based scientifically guided dosage regimen; the research team found no evidence of THC intoxication when using CBD-enriched whole plant extracts. “What makes these results really exciting is it opens up as a treatment option for kids; who have failed to respond to traditional medications,” said Dr. Richard Huntsman (MD), a pediatric neurologist who led the study.

Children very closely for side effects

“What is really important is that we have been able to dispel in a scientific manner some of the concerns about how to dose these products and the possibility of them causing a ‘high’ in these children. We did this by slowly increasing the dose of cannabis extract in a very tightly regulated manner. We watched the children very closely for side effects and measured blood levels of CBD and THC,” said Dr. Huntsman.

The children had drug-resistant epilepsy, failing to respond to at least two forms of anti-convulsant medication. They had been prescribed several anti-convulsant medications, yet continued to have seizures, with one child experiencing 1,223 in the month leading up to the study.

“We are very proud to support this important pediatric research, which is making such a difference in the lives of children who have severe epilepsy,” said Brynn Boback-Lane, president and CEO of Jim Pattison Children’s Hospital Foundation. “This groundbreaking study is giving hope and improved health outcomes. It is heartening to have donors that see the value of such important work.”

Helping to control epilepsy in children

Allyssa Sanderson’s eight-year-old son Ben from Prince Albert, Sask., was one of the participants in the study. Ben was born without complications, but later developed infantile spasms. When Ben was two, he was diagnosed with Lennox-Gastaut syndrome, a severe form of epilepsy. Despite trying multiple medications and treatments, Ben’s seizures were unpredictable. He was seizure-free on some days, but on others had 150 seizures a day.

Three of the seven children in the USask study mainly fund by Saskatchewan’s Jim Pattison Children’s Hospital Foundation; stopped having seizures altogether. “Some of the improvements in quality of life were really dramatic with some of the children having huge improvements; in their ability to communicate with their families. Some of these children started to talk or crawl for the first time. They became more interactive with their families and loved ones,” said Dr. Huntsman.

Several studies have shown that cannabis products containing CBD; can be effective in helping to control seizures in children with epileptic encephalopathy; a severe form of epilepsy which begins in childhood. Despite this, many children cannot access these products because there is very little guidance for physicians on which doses to use; and health-care providers are concerned about possible intoxication from THC.

Children very closely for side effects

This research found that most of the children had a reduction in seizures; with a twice daily dose of CBD totaling 5-6 milligrams of cannabis extract per kilogram of weight (mg/kg) per day. By the time a CBD dose of 10-12 mg/kg per day was achieve; all children experience a reduction in their seizures, most by more than 50 %.

“What is really important is that we have been able to dispel in a scientific manner some of the concerns; about how to dose these products and the possibility of them causing a ‘high’ in these children. We did this by slowly increasing the dose of cannabis extract in a very tightly regulated manner. We watch the children very closely for side effects and measure blood levels of CBD and THC,” said Dr. Huntsman.

The children had drug-resistant epilepsy; failing to respond to at least two forms of anti-convulsant medication. They had been prescribed several anti-convulsant medications; yet continued to have seizures, with one child experiencing 1,223 in the month leading up to the study.

“We are very proud to support this important pediatric research; which is making such a difference in the lives of children who have severe epilepsy,” said Brynn Boback-Lane, president and CEO of Jim Pattison Children’s Hospital Foundation. “This groundbreaking study is giving hope and improved health outcomes. It is heartening to have donors that see the value of such important work.”