All news from Nephrology

Chronic kidney disease

Itchy Skin Affects The Health With Kidney Disease

New research reveals that pruritus, or itchy skin, affects a substantial percentage of patients with chronic kidney disease (CKD). The study, which appears in an upcoming issue of the Clinical Journal of the American Society of Nephrology(CJASN); also indicates which patients are more likely to experience pruritus; demonstrates that pruritus may affect the quality of life…

Cognitive impairment

Mild Cognitive Impairment: Early Stages Of Kidney Disease

The link between brain dysfunction and advanced kidney disease was first noted in 1930; so it is not a new finding. Experts spoke of ‘dialysis dementia’ or ‘uremic encephalopathy’. What is new, however, is the finding that mild cognitive impairment (MCI) may already be present in earlier stages of CKD; affecting approximately one in two…

Immunotherapy drugs

NHS Patients With Advanced And Aggressive Kidney Cancer

A combination of immunotherapy drugs will make available to NHS patients with advanced and aggressive kidney cancer on the NHS in England. The drugs, nivolumab (Opdivo) and ipilimumab (Yervoy); can now use for previously untreated kidney cancer. The combination has shown to slow the progression of a certain type of kidney cancer compared with standard…

Vitamin D toxicity

Vitamin D: Linked To Kidney Damage

Vitamin D has reported having a wide range of benefits. However, a recent case study indicates that excessive use of vitamin D can cause kidney damage; in people who are not deficient in the vitamin. The aim of this case study is to inform a wider audience that vitamin D at large doses [10,000 IU…

Cabozantinib

Initial Dose Of Cabozantinib: Feasible In Advanced Renal Cell Carcinoma

Renal cell carcinoma (RCC) is a kidney cancer that originates in the lining of the proximal convoluted tubule; a part of the very small tubes in the kidney that transport primary urine. RCC is the most common type of kidney cancer in adults; responsible for approximately 90–95% of cases. Initial treatment is most commonly either partial or complete removal of…

Renal Hydatid Cyst

Renal Hydatid Cyst: A Rare Infectious Disease

Hydatid cyst is one of the most important zoonotic diseases by Cestoda Echinococcus, especially Echinococcus granulosus. The final hosts of the parasite are dogs and Canidae and the intermediate hosts are the livestock such as cows, sheep, and goats. The infection is by oral-fecal route and by parasite eggs; mostly due to consuming infected vegetables and food…

Dominant Polycystic Kidney Disease

The Autosomal Dominant Polycystic Kidney Disease

Every year worldwide, 4.8 to 15.3 per million persons with autosomal dominant polycystic kidney disease (ADPKD); progress to end-stage renal disease (ESRD). In Europe approximately 10% of all patients undergoing renal replacement therapy have ADPKD. In ADPKD patients; mutations in the genes encoding for either polycystin 1 or polycystin 2 result in polycystin complex dysfunction.…

Organ transplant

New Data Suggest: Kidney Allocation System Reform

Kidney transplantation or renal transplantation is the organ transplant of a kidney into a patient with end-stage renal disease. Kidney transplantation is typically classified as deceased-donor (formerly known as cadaveric) or living-donor transplantation depending on the source of the donor organ. Due to the implementation of the new kidney allocation system; highly sensitized kidney transplant recipients received more kidneys with lower kidney donor…

Blood pressure

Renal Denervation: A New Meta-Analysis

A new meta-analysis of six sham-controlled studies of renal sympathetic denervation (RSD); has shown a significant reduction in blood pressure with the technique. “After the SYMPLICITY HTN-3 trial, which failed to show a benefit of denervation; there was a loss of hope in this approach; but our results suggest there is something there, and denervation…

Chronic kidney disease

CKD: Undetermined Causes In Tropical And Subtropical

Chronic kidney disease of undetermined causes (CKDu); initially reported among agricultural communities in Central America and Sri Lanka, is also present in India, particularly in Southern rural areas, and could common in other tropical and subtropical rural settings. These are the main conclusions of a new study published in BMJ Open and in which the…

Chronic kidney toxicity

Contributes To Cisplatin-Induced CKD

Yale School of Medicine researchers have found that the progression of acute kidney injury to chronic kidney disease (CKD); caused by the use of the chemotherapy drug cisplatin is due to unresolved injury; sustained activation of regulated necrosis pathways rather than fibrosis. The new study is on the cover of the April 2019 issue of…

kidney disease

The Kidney Complications Garnering Attention At ISN

First results from a phase 3 trial of canagliflozin (Invokana, Janssen); in patients with type 2 diabetes and chronic kidney disease top the list of anticipated highlights at the upcoming International Society of Nephrology (ISN); 2019 World Congress. These findings could a big deal for patients with type 2 diabetes; said David Harris, MD, from the University of…