Microbiologist Showing That Disease Causing Bacteria

According to the study, microbiologist showing that disease causing bacteria; compete with their human hosts for a key micronutrient. Although queuine (pronounced KYOO-in) has been identified as essential to human health a 2018 study by Bruce Ames referred to it as a longevity vitamin much is still unknown about the compound; that humans must obtain from their natural gut bacteria, or secondarily, through dietary sources.

Usually, bacteria make queuine from scratch; in the UF/IFAS department of microbiology and cell science whose just publishing paper detailing the discovery appears in the journal PNAS. What we finding is that some bacteria that live in the human environment are not making it from scratch; instead, they are competing for the same micronutrients as the human host.

All multi-celled organisms rely on single-celled ones, bacteria, to synthesize queuine. But the human gut naturally has these queuine manufacturers; or they enter the body through the plant and animal sources we consume. Humans are able to recover the queuine we need through what are known as salvage enzymes.

Disease causing bacteria

It utilized computer-driven data mining to investigate queuine metabolism in two pathogenic, or disease-causing, bacteria; Chlamydia trachomatis, commonly known as the sexually transmitted disease chlamydia, and Clostridioides difficile, sometimes shortened to C. diff; that causes diarrhea and other intestinal issues and involves abnormal gut bacteria levels.

But the presence of queuine salvage enzymes in these bacteria; which making this competition possible, were a brand-new discovery; The organisms is essentially behaving like humans by not making its own queuine, instead stealing it through an enzymatic process that had not previously been describing. the bacteria of the microbiota and looking at all of the exchanges that occur. We want to try and model the interaction between bacteria in the gut and the host.

Substrate specificities

The first, found in the intracellular pathogen Chlamydia trachomatis, uses YhhQ and tRNA guanine transglycosylase (TGT) homologs that have changed substrate specificities to directly salvage q, mimicking the eukaryotic pathway. But the second, found in bacteria from the gut flora such as Clostridioides difficile, salvages preQ1 from q through an unprecedented reaction catalyzed by a newly defined subgroup of the radical-SAM enzyme family.

But the source of q can be external through transport by members of the energy-coupling factor (ECF); family or internal through hydrolysis of Q by a dedicating nucleosidase. But this work reinforces the concept that hosts; and members of their associated microbiota compete for the salvage of Q precursors micronutrients. At this time, queuine is both difficult and expensive to synthesize in a lab; It is not available in any sort of commercial supplements.