Hundreds of polymers which kill drug-resistant superbugs in novel ways could be produced and tested using light using a novel method developed at the University of Warwick. The research is published in the journal Chemistry; A European Journal.
The new methodology may help identify antimicrobials for a range of applications from personal care to coatings.
Researchers from the Department of Chemistry and Warwick Medical School developed a way to synthesize large libraries of polymers, in such a way to make their screening for antimicrobial activity faster, and without the need to use sealed vials.
By using multiple 'building blocks' in their polymers, new antimicrobials were identified – some of which appear to inhibit bacteria growth, contrary to predictions.
The benefit of the method is that it allows screening of hundreds of different structures, enabling the researchers to 'go fishing' for new properties, which in this case was antibiotic activity.
Antimicrobials are essential not just in the treatment of internal disease and infections, but also in personal care products, such as contact lenses or shampoo, in foods, or as topical creams.
Awareness of antimicrobial resistance
There is the growing awareness of antimicrobial resistance and the need to develop innovative solutions to tackle microbial infection. Traditional antimicrobials (such as penicillin) work by inhibiting key cellular processes.
The Warwick team, led by Professor Matthew Gibson, were instead inspired by host-defense peptides which are broad-spectrum antimicrobials and function by breaking apart the membrane of bacteria.
Whilst many people have successfully mimicked antimicrobial peptides with polymers, the limiting step was the number of different combinations of building blocks you can use.
We used simple robotics and a light controlled polymerization, which lets us do the chemistry open to air, without any sealed vials which are essential for most polymer syntheses" Professor Matthew Gibson, Lead Author.