All news from Medical Toxicology

CAR T-Cell Therapy

The Neurological Side Effects of CAR T-Cell Therapy

The recent advent of chimeric antigen receptor (CAR) T-cell therapy has revolutionized the clinical treatment of cancer. Under the umbrella of immunotherapy, CAR T-cell treatment trains and strengthens a patient’s own immune system to attack tumors. Early successes in clinical trials have led to approval of the treatment for recurrent blood cancers, including leukemia and…

Charcoal-based toothpaste

Charcoal-Based Toothpaste Comes With ‘Real Risks’

Writing in the British Dental Journal, scientists have concluded that there are no proven benefits for toothpaste containing activated charcoal and that it may actually increase the risk of tooth decay and staining. But the research is in stark contrast to marketing that claims charcoal toothpaste; has whitening and antibacterial benefits, among many others. Activated charcoal,…

Opioid use disorder

Ethnic Disparities In Access To Buprenorphine

Racial and ethnic minorities with opioid use disorder (OUD); have a significantly lower odds of receiving a prescription for buprenorphine compared with their white counterparts; new research shows. Investigators used two large databases that included 13.4 million outpatient visits in 2012-2015 to compare buprenorphine prescriptions; in white patients versus those of other races and ethnicities.…

Fluoridated water

Fluoride: Dental Risk From Minimal And Extended Breastfeeding

Despite advances in prevention, dental caries remains a significant global health burden. Dental health in Australia has improved considerably, but 40% of children had experienced dental caries. Globally, it has proved particularly difficult to reduce caries in primary teeth, and this remains a disease of significant health, social, and economic importance. The benefits of breastfeeding…

Pregnancy-death

Opioids: Pregnancy-Related Death In New Utah Moms

The researcher new study at the University of Utah Health found that drug-induced death is the most common cause of pregnancy-death in Utah. Postpartum women who have previously or currently struggle with substance abuse are at greater risk of overdosing. The research team explored the need for continued substance abuse counseling; access to naloxone prescriptions…

Cell death

Adverse Events Common With PD-1 And PD-L1 Inhibitors

Most cancer patients treated with programmed cell death (PD-1) and programmed cell death ligand 1 (PD-L1); inhibitors experience at least one treatment-related adverse event; according to a new systematic review and meta-analysis. “The researcher comprehensive meta-analysis of adverse events from PD-1 and PD-L1 inhibitors in clinical trials will an important guide for clinical practice,” Dr.…

Oral fluoroquinolone

Oral Fluoroquinolones: Small Risk Of Peripheral Neuropathy

Oral fluoroquinolone exposure is with a small increase in the risk of peripheral neuropathy; according to findings from The Health Improvement Network (THIN) database. Peripheral neuropathy is one of several side effects that may occur following fluoroquinolone therapy, and other antibiotics have side effects, too. “Therefore, antibiotic stewardship is critically important to ensure these valuable…

Dementia Risk

Hormone Therapy For Prostate Cancer Raise Dementia Risk

When men with prostate cancer have to take drugs that block the testosterone fueling their tumors; they can suffer a host of side effects that include impotence, bone loss, heart trouble, and obesity. But new research uncovers yet another possible downside to the treatment: These men may be at greater risk for dementia. For any…

Marmot Meat

Dies Of Plague After Eating Raw Marmot Meat

The Tarbagan marmot (Marmota sibirica) is a species of rodent in the family Sciuridae. It is in China (Inner Mongolia and Heilongjiang); northern and western Mongolia, and Russia (southwest Siberia, Tuva, Transbaikalia). In the Mongolian Altai, the range overlaps with that of the Gray marmot. The species was classified as endangered by the IUCN in 2008. The tarbagan marmot has eaten for centuries in the native…

Arsenic

Arsenic: Drinking Water May Change Heart Structure

Drinking water that is contaminating with arsenic may lead to thickening of the heart’s main pumping chamber in young adults; a structural change that increases the risk for future heart problems; according to new research in Circulation: Cardiovascular Imaging, an American Heart Association journal. People drinking water from private wells, which are not regulated; need…

Raw chicken

Warning Against Washing Raw Chicken Before Cooking

The Centers for Disease Control and Prevention (CDC); have issued another warning against washing raw chicken before cooking. They warn of the risk of spreading harmful bacteria to other food or utensils and developing food poisoning at home. The CDC estimates that approximately a million people become ill after eating contaminated poultry. According to the…

Cirrhosis

Leukopenia In Patients With Autoimmune Hepatitis And Related Cirrhosis

Autoimmune hepatitis (AIH) is a chronic self-perpetuating inflammatory liver disease by increased serum aminotransferase levels and autoantibodies; elevated serum immunoglobulin G (IgG) concentration, lymphoplasmacytic infiltration of the portal tract; interface hepatitis. Misdiagnosis or treatment failure can lead to liver cirrhosis, liver cancer, liver transplantation, and rapid death. The first-line treatment for AIH involves predniso(lo)ne as…