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Medical genetics

Health Records Pin Broad Set Of Health Risks On Genetic

In a study published Aug. 21 in Science Advances, a team led by Marsha Mailick, a researcher and professor at UW-Madison’s Waisman Center, and UW-Madison graduate student Arezoo Movaghar provide a better understanding of the previously disputed relationship between this well-known genetic premutation and a wide range of clinical conditions. At the same time, the interdisciplinary study richly…

Medical genetics

BRCA1/2 Genetic Testing Recommendations Still Leave Issues

The study find that The U.S. Preventive Services Task Force (USPSTF) has released a new Recommendation Statement for BRCA1/2 evaluation, urging the medical community to widen the parameters used to assess BRCA1 and BRCA2 mutation risks and increase the use of genetic counseling and testing for those with the highest risk. While the changes are beneficial; the recommendations still fail…

Medical genetics

New Targets For Chromatin Remodeling Mutations Identified

The study find that the all human cancers harbor mutations in one of the members of the BAF chromatin remodeling complex. Deep biochemical and epigenomic characterization of a cell line panel comprehensively representing all these mutations enabled researchers at the CeMM Research Center for Molecule Medicine of the Austrian Academy of Sciences to identify new…

Medical genetics

Interregional Differences In Somatic Genetic Landscape

The study find that the Clinical Research and medical institutes participating in the Kansai Molecular Diagnosis Network for CNS Tumors (KNBTG), conducted the largest-ever retrospective cohort study for Japanese patients with glioblastoma (GBM), proposing an underlying prognosis biomarker responsible for the survival difference between two cohorts: an original Japanese cohort and a dataset from The…

Biologists Pioneer First Method To Decode Gene Expression

Biologists Pioneer First Method To Decode Gene Expression

Given the recent remarkable advancements in genetics, it’s easy to assume that 21st century scientists have at their disposal a clear, quick way to run a genomic sequence scan and find out which genes among thousands can be expressed and which cannot. Gene expression is the process by; which information encoded within genes leads to…

Medical genetics

A Dominant-Negative Effect With TP53 Mutations

The study find that  A large team of researchers affiliated with several institutions in the U.S. and one in Germany has found evidence that makes a case for a dominant-negative effect with TP53 mutations. In their paper published in the journal Science, the group describes their study of such gene mutations and their work; which…

Medical genetics

The Hidden Changes In DNA That Produce New Diseases

The researches find that the Environmental change is one of the things that can produce big; serious mutations in our DNA that can quickly lead to disease; such as cancer caused by radiation. But our DNA also contains many tiny hidden mutations. While they initially have no effect on us thanks to a box of…

Medical genetics

Individual Differences In Pleasure Are Due To Genetic Variation

The researches find that a financial reward are due, in part, to genetic differences, according to research with identical and fraternal twins published in Psychological Science, a journal of the Association for Psychological Science. The findings suggest that how we experience pleasure and reward is at least partly heritable. Therefore The brain’s reward system plays…

Medical genetics

DNA Modifications To Alter Breast Cancer Outcomes

New findings suggest that women with specific DNA characteristics in certain areas of the genome may live longer if they take aspirin before they are diagnosed with breast cancer. Published early online in CANCER; a peer-reviewed journal of the American Cancer Society; the findings point to the need for studies on the potential of aspirin to…

Medical genetics

Combination Of Two Gene Mutations Is Linked To Endometrial Cancer

The Van Andel Institute, have identified a combination of two gene mutations that is linked to endometrial cancer. “More than 63,000 women are likely to be diagnose with endometrial cancer this year; making it the most commonly identify type of gynecologic cancer;” said Ronald Chandler, an assistant professor of obstetrics, gynecology and reproductive biology in the College…

Medical genetics

Genetic Sequences Of People With Epilepsy

The study find that the patients from Austin Health and the University of Melbourne have been involved in the largest ever study looking at the genetic sequences of people with epilepsy. The international research; published this week in the American Journal of Human Genetics; involved almost 18,000 people worldwide and identified rare genetic variations that associated…

Medical genetics

People’s Unique Genetic Makeup Offers Clues To Disease

The study find that the unique genetic history of the people of Finland to identify variations in DNA that might predispose certain individuals to disease, whether or not they are Finnish themselves. The study was conducted by researchers at Washington University School of Medicine in St. Louis, in collaboration with the University of California, Los…