The same aspects of relatively recent evolutionary changes that make us prone to bad backs and impacted third molars may have generated long, noncoding stretches of DNA that predispose individuals to schizophrenia, bipolar disorder, and other neuropsychiatric diseases
All news from Medical Genetics
Researchers have identified a gene that when inhibited or reduced, in turn, reduced or prevented human non-small cell lung cancer tumors from growing.
Most people are familiar with A, B, AB and O blood types, but there are hundreds of additional blood group "antigens" on red blood cells—substances that can trigger the body's immune response—that differ from person to person. Each year, up to 16 deaths reported to the Federal Drug Administration are attributed to mismatches in red blood cell antigens that are not related to differences in A, B, and O blood groups.
Currently, no method is available that can determine all blood antigens. But as whole genome sequencing becomes routine for patients, it may be possible to modernize therapy by identifying both rare donors and at-risk recipients before blood transfusions.
Mutations in genes that help repair damage to DNA may aid in predicting the prognosis of patients with bladder and other related cancers, according to researchers.
The researchers at the University of Minnesota and the University of Toronto examines for the first time how higher-order gene combinations–-comprising three genes–-help maintain normal cell physiology. The findings, reported in the journal American Association for the Advancement of Science (AAAS), could help develop new life-saving treatments to combat diseases such as cancer, heart disease, and diabetes.
In a powerful example of bench-to-bedside science showing how observations made in the lab can spark life-altering therapies in clinic, an international team of clinician-investigators has announced that gene therapy for patients with a severe form of the blood disorder beta-thalassemia can be safe and effective.
The Epstein-Barr virus (EBV) — best known for causing mononucleosis — also increases the risks for some people of developing seven other major diseases, according to a new study.
The diseases are systemic lupus erythematosus, multiple sclerosis, rheumatoid arthritis, juvenile idiopathic arthritis, inflammatory bowel disease, celiac disease, and type 1 diabetes. Combined, these diseases affect nearly 8 million people in the US.
A scientific study conducted at the State University of Campinas (UNICAMP) in São Paulo State, Brazil, has identified genetic factors associated with the severity of acute viral bronchiolitis. The study was supported by the Sao Paulo Research Foundation – FAPESP. The results were published in the journal Gene.
VCU Massey Cancer Center has identified two genes that might be responsible for the replication of the Epstein-Barr virus, an infection that drives the growth of several types of cancer. The discovery could lead to the novel therapies for cancer.
A new study had identified a direct cooperation between two cancer genes which paves the way for targeted treatments, not only in Acute lymphoblastic leukemia but also in other leukemias where JAK3/STAT5 could have cooperated with HOXA9.
The study describes an approach to modeling the characteristics of early human cardiac organogenesis , which creates the necessary geometric confinement to drive the spatial organization of human induced pluripotent stem cells (hiPSCs).