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Medical genetics

New Gene Regions Associated With Sleep Duration Identified

A study led by investigators from Massachusetts General Hospital and the University of Exeter Medical School has identified 76 new gene regions associated with sleep duration. The study by a team that recently reported finding gene sites associated with insomnia risk and chronotype – the tendency to be an early riser or a ‘night owl’ …

Medical genetics

Genetic Study Confirms That Many Genes Contribute To Risk For Tourette's Syndrome

A meta-analysis of multiple studies into the genetic background of Tourette’s syndrome (TS) a neurodevelopmental disorder characterized by chronic involuntary motor and vocal tics finds that variants in hundreds of genes, working in combination, contribute to the development of the syndrome and suggests that Tourette’s is part of a continuous spectrum of tic disorders, ranging…

Medical genetics

Novel Mechanism Behind DNA Damage Control Uncovered

DNA damage is occurring in our cells all the time due to external agents; such as exposure to sun, or internal agents, like reactive oxygen species. To detect and repair DNA lesions, cells have evolved DNA damage response. Activation of this response underpins genome integrity; which is crucial for preventing the onset of many human…

Medical genetics

Developing Novel Gene Therapy To Cure Crigler-Najjar Syndrome

Because of a defective gene, these individuals lack an essential enzyme in their liver to eliminate bilirubin, a toxic bile pigment that accumulates in all body tissues causing jaundice and potentially leading to irreversible and lethal neurological damage. Researchers from the EU-funded CURECN project are studying that defective gene, known as UGT1A1, and developing and…

Medical Genetics

Some Personal Beliefs And Morals May Stem From Genetics

A new baby is often welcomed with speculation about whether they got their eyes and nose from mom or dad; but researchers say it may be possible for children to inherit their parents’ moral characteristics, as well. The researchers found that while parents can help encourage their children to develop into responsible; conscientious adults, there…

Medical Medical genetics

Oxford Nanopore Launches New cDNA Kits For Its Sequencing Technology

Oxford Nanopore has launched new ‘109’ cDNA Kits for its real-time; scalable sequencing technology. The new kits provide high throughput whilst generating complete sequences of full-length cDNA strands, with a low input option of just 1ng PolyA+ RNA. because The new cDNA sequencing method enables users to sequence whole transcriptomes to high coverage on a…

Medical Genetics

Tests Suggest Scientists Achieved First 'In Body' Gene Editing

Scientists think they have achieved the first gene editing inside the body, altering DNA in adults to try to treat a disease, although it’s too soon to know if this will help. Preliminary results suggest that two men with a rare disorder now have a corrective gene at very low levels, which may not be…

Medical Genetic

Geneticists Identify Molecular Pathway For Autism Related Disorder

Geneticists discovered a molecular trigger for a severe autism-related disorder that has enabled them to start testing a potential therapy targeting a specific protein in the brain. A UT Southwestern study involving humans and mice details one of the few instances in which researchers have found a precise pathway that causes; a neurodevelopmental disorder in…

Medical Genetics

Aging And Chronic Diseases Share Genetic Factors

The global population age 60 or over is growing faster than all younger age groups and faces the tide of chronic diseases threatening their quality of life and posing challenges to healthcare and economic systems. To better understand the underlying biology behind health span the healthy period of life before the first chronic disease manifestation…

Medical Genetics

Gene Therapy Cassettes Improved For Muscular Dystrophy

Experimental gene therapy cassettes for Duchenne muscular dystrophy have been modified to deliver better performance. The cassettes, which carry the therapy into muscle cells, contain newer versions of a miniaturized treatment gene. The micro-dystrophin, as the treatment is called, has been restructured to enhance its functionality. Revamped versions The revamped versions are develope and tests…

Medical genetics

GARFIELD Classifies Disease Relevant Changes In The Genome

Researchers at the Wellcome Sanger Institute and EMBL’s European Bioinformatics Institute (EMBL-EBI) have developed a new approach to understanding the functional effects of genetic variations associated with a disease, even if they aren’t located in a gene. Using this approach could help scientists uncover previously unknown mechanisms that control gene activity and determine whether cell…