Polyketides synthesized by polyketide synthases (PKS) are a large class of natural products with diverse structures and biological activities. The structural variations of polyketides are attributing to the post-modification by tailoring enzymes and or a hybrid pathway; such as polyketide synthases−non-ribosomal peptide synthase (PKS-NRPS). β-Lactone featuring a strained four-membered oxygen heterocycle is a rare structural…
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A field survey conducted by a team of marine scientists from the National University of Singapore (NUS) has uncovered toxic bacteria living on the surfaces of microplastics; which are pieces of plastic smaller than 5 millimeters in size; collected from the coastal areas of Singapore. These bacteria are capable of causing coral bleaching and triggering…
Compounds found in fish oil prevent pregnancy complications, including preterm birth, neonatal death, and stillbirth, in mice when the complications are caused by a common oral bacteria, according to research published today in the journal JCI Insight. The study, by scientists at Columbia University’s College of Dental Medicine and Vagelos College of Physicians & Surgeons, suggests…
Fish oil does not appear to improve asthma control in adolescents and young adults with uncontrolled asthma who are overweight or obese, according to new research published online in the Annals of the American Thoracic Society.
Macroalgae have been reported as an important source of halogenated aromatic secondary metabolites, being the majority of these derivatives isolated from red algae. Halophenols and haloindoles are the most common haloaryl secondary metabolites isolated from these marine organisms. Nevertheless, some halogenated aromatic sesquiterpenes and naphthalene derivatives have also been isolated.
The understanding of cell death used to consist in necrosis, an unregulated form, and apoptosis, regulated cell death. That understanding expanded to acknowledge that apoptosis happens through the intrinsic or extrinsic pathways. Actually, many other regulated cell death processes exist, including necroptosis, a regulated form of necrosis, and autophagy-dependent cell death.
Marine and salmon polar lipids (PLs) extracted by conventional extractions with non-food-grade solvents (CE-salmon-PLs) possess antithrombotic bioactivities against platelet-activating factor (PAF) and thrombin. Similar effects of food-grade-extracted (FGE) marine PLs have not yet been reported.
The jury has returned, and the verdict is in: If you treat dry eye disease with a protocol that includes purified fish oil, your patients will feel better. Seriously. It says so right there in the results section of the DREAM study.
Bisphosphonates (BPs) are one of the most widely used bone resorption inhibitor drugs for the management of skeletal diseases such as osteoporosis, Paget’s disease, multiple myeloma, and complications from metastatic malignancy.
A recent study showed enhanced bioavailability of the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) administered in a proprietary self-micro-emulsifying delivery system (SMEDS) formulation compared to a standard ethyl ester delivery.