Serum Inflammatory Markers Used In Recovery

Blood biomarkers may predict concussion recovery; by the levels of serum inflammatory markers may be useful in identifying; which athletes are more likely to require a longer recovery time after a sport-relating concussion. In addition, post-concussion IL-6 levels were significantly associating with the duration of concussion symptoms.

The study conducting in a total of 857 high school and college football players were enrolling in the study. Of these, 41 concussing athletes and 43 matching control athletes who did not sustain a concussion during football season met the study’s inclusion criteria.

Serum inflammatory markers

All athletes underwent blood testing at the start of the football season. Those with concussions had blood tests within 6 hours after their concussion and again at 24 to 48 hours post-injury. Concussed athletes also had blood samples drawn 8, 15, and 45 days later. The control group had blood testing at similar times for comparison purposes.

In addition, athletes with higher levels of IL-6 six hours after the injury were more likely to take longer to recover from their symptoms. Overall, those with concussion had symptoms for an average of 8.9 days. Eight of the 17 athletes with concussion and high IL-6 levels at 6 hours after injury still had symptoms 8 days later.

Initial symptoms

But the study showing that this marker has some added value; because right now the most predictive factor for prolonged symptoms is how severe the initial symptoms. There are obviously concerns around relying on self-reported symptoms from athletes because they tend to underreport their symptoms as their report dictates when they return to play.

The researchers also plan to investigate the combined diagnostic; and prognostic potential of blood biomarkers to capture multiple aspects of the neurometabolic cascade, as well as the relationship with other potential biomarkers; including neuroimaging metrics. The team is also conducting ongoing research comparing inflammatory; and other blood markers to non-football athletes as a secondary control group; in order to account for the potential effects of repetitive blows to the head; that occur in football players without diagnosed concussion.