New Biomarkers For Irritable Bowel Syndrome In Urine

The identification of the new biomarkers for Irritable Bowel Syndrome (IBS) in urine; which could lead to better treatments and reduce the need for costly; and invasive colonoscopy procedures currently used for diagnosis. Researchers performing metabolite profiling studies; comparing urine samples from a cohort of IBS patients with a control group of healthy adults.

Irritable Bowel Syndrome, a chronic and often debilitating gastrointestinal disorder; which affects hundreds of thousands of Canadians in which diagnosis is complicating; patients experience a vast spectrum of symptoms and treatment options are limiting. Diagnostic testing for IBS involves a long process of excluding other related gut disorders, such as inflammatory bowel disease.

Irritable bowel syndrome

But the study discovering for the first time distinctive metabolic signatures; that were elevating in the IBS patients. Several metabolites were related to collagen degradation; which researchers believe is derived from the gut, suggesting there is an impairment of the elastic lining in the colon impacting its normal function.

Researchers believe the findings might also allow for routine treatment monitoring of IBS patients that can also be using to validate the efficacy of dietary and/or pharmacological interventions. But by finding if there is a better way to detect and monitor irritable bowel syndrome; that avoids invasive colonoscopy procedures while also giving us better insights into its underlying mechanisms.

Biomarkers in urine

But currently, study expanding their work to discover new biomarkers in urine that can differentiate Crohn’s disease from ulcerative colitis in children, hoping they can avoid future colonoscopies altogether. This may allow for rapid screening and early detection of various chronic gut disorders more accurately and at a lower cost.

But several metabolites were related to collagen degradation, which researchers believe is derived from the gut, suggesting there is an impairment of the elastic lining in the colon impacting its normal function. which could lead to better treatments and reduce the need for costly and invasive colonoscopy procedures currently used for diagnosis.