Measurable Indicator Biomarkers For Alzheimer's disease

As biological marker is a measurable indicator of some biological state or condition of an disease. In this the study explaining; the abnormal accumulation of proteins in the brain is a biological marker for Alzheimer’s disease.

The study identifying differences in the spread of a protein calling tau which is linking to cognitive impairment between men and women; with women showing a larger brain-wide accumulation of tau than men due to an accelerating brain-wide spread. Accumulating evidence suggests that tau spreads through brain tissue like an infection; traveling from neuron to neuron and turning other proteins into abnormal tangles, subsequently killing brain cells.

Measurable indicator

But by using data from positron emission tomography scans of healthy individuals and patients with mild cognitive impairment who were enrolling in the Alzheimer’s Disease Neuroimaging Initiative  database; CCI researchers constructing in vivo networks modeling tau spread using graph theory analysis.

The results of the analysis showed the architecture of tau networks is different in men and women; with women having a larger number of bridging regions; that connect various communities in the brain. But this difference may allow tau to spread more easily between regions; boosting the speed at which it accumulates and putting women at greater risk for developing Alzheimer’s disease.

Different biological processes

However, the study accelerating spread of tau in women; may indicate a need for sex-specific approaches for the prevention of Alzheimer’s disease, including earlier therapies; lifestyle interventions and/or cognitive remediation.

Understanding how different biological processes influence our memory is a really important topic. Sex-specific differences in the brain’s pathological, neuroanatomical and functional organization may map into differences at a neurobehavioral and cognitive level, thus explaining differences in the prevalence of neurodegenerative disorders and helping us develop appropriate treatments.