Challenges Of Consistently Diagnosing Child Blood Samples

According to the study, researchers investigating challenges of testing children’s blood; were highlighting the challenges of consistently diagnosing child blood samples; and sourcing healthy samples for research. As the study saying that laboratories test whether levels of blood biomarkers (like sodium and potassium) are within a normal range but defining normal can be difficult, especially when it comes to children.

Pediatric reference intervals across 5 analyzers; using the blood samples of 616 healthy children and finding that results from different laboratories were not always uniform. Getting access to the blood of healthy people can be problematic, especially when it comes to children and newborns. While parents are generally not reluctant to get their children to donate blood for research, children can only donate small amounts of blood, a factor that can create difficulties.

Child blood samples

But the variations in results were either due to differences; in how the blood was testing or because specific blood reference values for children are needed. Better reference intervals (which define the normal range) could help improve clinical decisions in children around the world. Clinical laboratory test results are critical to evidence-based medicine, with nearly 80 percent of physicians’ decisions based on information provided by laboratory reports.

The study examined the results of tests for 30 blood biomarkers; producing by five different automating blood analyzing machines. Results from the five analyzers were mostly within the ‘allowable error’ margin, however there were some variation. For creatinine, a waste product produced by muscles, levels varied by 11.9 percent between machines. Whether patient samples tested at different laboratories, using different analyzing machines, can be directly compared is of global importance.

Facilitate improvements

But lack of regulatory incentives for manufacturers of lab machines; may be contributing to lack of data on pediatric specific reference intervals and that changes to regulations could facilitate improvements in availability of age-specific reference ranges. This would help improve clinical result interpretation and decision making. the need for consistent blood diagnosis; is even more crucial when a child’s care is shared by a specialist, central hospital and local health care providers.

However, for the study, blood was taken from 616 child participants aged a few hours old to 17 years. Of the 30 blood biomarkers assessed; results varied statistically and clinically for six of the 30. Until now no study has compared the reference values obtained by testing samples from same individuals on five analyzer machines using blood samples; from healthy newborns and children. The child participants are part of the Harmonizing Age Pathology Parameters in Kids (HAPPI Kids) study a prospective, cross-sectional study of pediatric blood samples; for commonly requested biomarkers.