Biochemical Markers Among Hemodialysis Patients

Islamic lunar calendar during which all healthy adult Muslims are requiring to abstain from eating any food and drinks from dawn to sunset; with special exceptions for those severely ill; menstruating females; pre pubertal children and travelers; The effect of Ramadan fasting on physiological and biochemical markers among healthy individuals has been widely studying.

Research evidence suggesting that Ramadan fasting is tolerable and safe for healthy adults; Several studies have examining the effect of Ramadan fasting on physiological and biomedical markers in patients with kidney diseases. Ramadan fasting was not associated with significant adverse effects in kidney transplant patients after one year of kidney transplantation; or urinary risk factors for calculus formation.

Biochemical  markers for hemodialysis

But the study assessing the effects of daily ramadan fasting and partial Ramadan fasting on key biochemical and clinical markers among hemodialysis patients in comparison to hemodialysis patients who did not fast during Ramadan. After controlling for within person variation; sociodemographic and significant comorbidities.

The reason for increase in serum potassium in RFG in the current study is not clear. However, one potential explanation is increased consumption of Ramadan’s festive foods rich in potassium (e.g. dates, apricot, watermelon, sweets, carbonated soft drinks, squash, tea and coffee), which is traditional in Palestine and other middle eastern countries; Another explanation is insulin suppression due to fasting (insuliopenia), causing shift of potassium from the intracellular to the extracellular space.

Symptoms of hyperkalemia

Although the evidence from this study suggests that Ramadan fasting by hemodialysis patients is not associating with clinically significant complications; it highlights that these patients may be at risk of hyperkalemia and fluid overload. Therefore, the hemodialysis patients who intend to fast during Ramadan should be made aware of these potential complications.

Additionally, these patients should be monitoring closely for signs and symptoms of hyperkalemia and fluid overloading. They should also be advising to avoid exceeding their daily fluid allowing and limit their intake of food rich in potassium. Therefore, they should be closely monitoring and instructing to adhere to their daily fluid allowance and limit their consumption of food rich in potassium.