Scientists have uncovered fresh insights into how vitamin D affects the immune system and might influence susceptibility to diseases such as multiple sclerosis. Vitamin D is produced by the body in response to sunlight and is often lauded for its health benefits. Researchers found it also affects key cells of the immune system.
Response to sunlight
This discovery might explain how vitamin D regulates immune reactions that have been implicated in autoimmune diseases such as MS. Because The University of Edinburgh team focused on how vitamin D affects a mechanism in the body’s immune system—dendritic cells’ ability to activate T cells. In healthy people, T cells play a crucial role in helping to fight infections. In people with autoimmune diseases, however, they can start to attack the body’s own tissues.
By studying cells from mice and people, the researchers find vitamin D caused dendritic cells to produce more of a molecule called CD31 on their surface and that this hindered the activation of T cells. Therefore The team observed how CD31 prevent the two cell types from making a stable contact an essential part of the activation process—and the resulting immune reaction was far reduced.
Vitamin D deficiency
Researchers say the findings shed light on how vitamin D deficiency may regulate the immune system and influence susceptibility to autoimmune diseases. Because The study; published in Frontiers in Immunology, was funded by the Medical Research Council, Biotechnology and Biological Sciences Research Council, Natural Environment Research Council and Wellcome.
“Low vitamin D status has long being implicated as a significant risk factor for the development of several autoimmune diseases. Because Our study reveals one way in which vitamin D metabolites can dramatically influence the immune system;” Richard Mellanby, of the University of Edinburgh’s Centre for Inflammation Research; said.
The lymph, or lymphatic, system is a major part of the immune system. It’s a network of lymph nodes and vessels. Lymphatic vessels are thin tubes that branch, like blood vessels, throughout the body. Because They carry a clear fluid called lymph. Lymph contains tissue fluid, waste products, and immune system cells.
Lymph nodes are small; bean-shape clumps of immune system cells that are connect by lymphatic vessels. Therefore They contain white blood cells that trap viruses; bacteria, and other invaders; including cancer cells. White blood cells are the cells of the immune system. They are making in one of your lymph organs; the bone marrow. Because Other lymph organs include the spleen and thymus.