Researchers have shown that cancer immunotherapy targeting the tumor biomarker epithelial cell adhesion molecule (EpCAM) is safe and nontoxic in mice and can significantly delay tumor formation and growth. EpCAM is overexpressed in various tumor types, circulating tumor cells, and tumor stem cells, giving these findings broad implications. The study design and results are publish in a Special Issue on Immune Gene Therapy in Human Gene Therapy, a peer-review journal from Mary Ann Liebert, Inc., publishers.
Adi Barzel, PhD, Tel-Aviv University and President of The Israeli Society of Gene and Cell Therapy is Guest Editor of the Special Issue. The full issue will be published in April 2019. The article entitled “Preclinical Evaluation of Chimeric Antigen Receptor-Modified T Cells Specific to EpCAM for Treating Colorectal Cancer” was coauthored by Wei Wang and a team of researchers from West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy (Chengdu, China) and First Affiliated Hospital of Chongqing Medical University (China).
The researchers produced third generation chimeric antigen receptor-modified T (CAR-T) cells. They used a lentiviral vector to target the cells specifically to EpCAM. “CAR-T cell technology represents a breakthrough therapy for patients with B cell leukemias and lymphomas, but progress with solid tumors has, unfortunately, been much slower,” says Editor-in-Chief Terence R. Flotte, MD, Celia and Isaac Haidak Professor of Medical Education and Dean, Provost, and Executive Deputy Chancellor; University of Massachusetts Medical School, Worcester, MA.
“This pivotal study in patients with colorectal cancer demonstrates that targeted cancer immunotherapy could indeed have a role in this very common malignancy.”the Official Journal of the European Society of Gene and Cell Therapy; British Society for Gene and Cell Therapy, French Society of Cell and Gene Therapy; therefore German Society of Gene Therapy, and five other gene therapy societies; therefore is an authoritative peer-review journal publish monthly in print and online.
Led by Editor-in-Chief Terence R. Flotte, MD, Celia and Isaac Haidak Professor of Medical Education and Dean, Provost, and Executive Deputy Chancellor; University of Massachusetts Medical School, Human Gene Therapy presents reports on the transfer and expression of genes in mammals; including humans.
Gene therapy products
Related topics include improvements in vector development, delivery systems; and animal models, particularly in the areas of cancer, heart disease, viral disease, genetic disease, and neurological disease; as well as ethical, legal, and regulatory issues related to the gene transfer in humans.
Its companion journals, Human Gene Therapy Methods, published bimonthly; focuses on the application of gene therapy to product testing and development; and Human Gene Therapy Clinical Development; published quarterly, therefore features data relevant to the regulatory review and commercial development of cell and gene therapy products. Tables of contents for all three publications and a free sample issue may be view on the Human Gene Therapy website.