All news from Immuno Haematology & Blood Transfusion

Lipoprotein alterations linked to sickle cell disease pathology

Imbalances in lipoprotein metabolism have been associated with vaso-occlusive events in individuals with sickle cell disease (SCD). The research, led by Dr. Eric Soupene in Dr. Frans Kuypers' laboratory, identified high-density lipoprotein (HDL) metabolites in SCD plasma that enhance inflammation and diminish the effectiveness of current therapies. This study has been published in Experimental Biology and Medicine.