A new program project grant from the National Cancer Institute (NCI) will fund research by the Translational Center of Excellence for Lung Cancer Immunology at the Abramson Cancer Center of the University of Pennsylvania to improve the effectiveness of chimeric antigen receptor (CAR) T cell therapy at fighting solid tumors.
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If we really want to know how our body's cells work or do not work, in the case of disease we might need to look beyond their genes and even beyond the proteins, they are made of. We may need to start going through the cellular "trash."
Patients with an aggressive form of advanced breast cancer can benefit from immunotherapy when used in combination with chemotherapy as first-line treatment, according to the results of a large international Phase III clinical trial and led by a researcher at the UPMC Hillman Cancer Center.
Scientists at the Oklahoma Medical Research Foundation have broken new ground in understanding how the lymphatic system works, potentially opening the door for future therapies. The lymphatic system is a network of vessels and lymph nodes that spans the entire body.
A team of researchers from Switzerland, the U.S., and Spain has isolated an enzyme that triggers an autoimmune response from T-cells in patients with MS. In their paper published in the journal Science Translational Medicine, the group describes their study of T-cells and protein fragments and what they found.
About 15% of breast cancers are classified as triple-negative, lacking receptors for estrogen, progesterone, and Her2. These cancers do not respond to targeted hormonal therapies, and they tend to be particularly aggressive, often resisting systemic chemotherapy and metastasizing to other tissues.
A team of researchers from the University of Zurich and the University Hospital Zurich has shown that in multiple sclerosis it is not only specific T cells that cause inflammation and lesions in the brain. B cells, a different type of immune cell, also play a role.
Systemic sclerosis (SSc, also known as scleroderma), a connective tissue disorder of autoimmune etiology, is characterized by excessive fibrosis in the skin and various internal organs.
Macrophages are specialized immune cells that destroy bacteria and other harmful organisms. Scientists at KU Leuven, Belgium, have come to the surprising conclusion that some macrophages in the intestines of mice can survive for quite some time.
Pediatric researchers have identified a gene mutation that causes a serious lymphatic condition and used that knowledge to restore normal lymphatic vessels in model animals. The laboratory findings may lead to a new therapy for patients with this type of abnormal lymphatic circulation.
Scientists at the VIB-UGent Center for Medical Biotechnology have taken important steps toward the development of cancer-targeting immunotherapy. The research team developed a treatment in mice that destroys part of the tumor and stimulates the immune system to attack persistent surviving cancer cells.