Due to their powerful tumor-killing effect, metal-based chemotherapies are frequently used in cancer treatment. However, it was hitherto assumed that they damaged the immune system, because of their cytotoxic (cell-damaging) effect even against dividing healthy cells.
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A new study has shown that overactive immune systems may be the trigger that gives rise to chronic fatigue syndrome (CFS). The study results were published in the latest issue of the journal Psychoneuroendocrinology.
NK cells, or natural killer cells, play an important role in the body's defenses against cancer and various infections. Now, in a joint project, researchers at Lund University in Sweden, the University of Oxford and Karolinska Institutet in Stockholm have mapped how the different steps of the maturation process of these supercells from blood-producing stem cells in the bone marrow are regulated: knowledge which is crucial for the development of new immunotherapies against cancer.
The elderly suffer more serious complications from infections and benefit less from the vaccination than the general population. Scientists have long known that a weakened immune system is to blame but the exact mechanisms behind this lagging immunity have remained largely unknown.
The elderly suffer more serious complications from infections and benefit less from vaccination than the general population. Scientists have long known that a weakened immune system is to blame but the exact mechanisms behind this lagging immunity have remained largely unknown.
The Allen Institute today announced the launch of the Allen Institute for Immunology, a new division of the Institute that is dedicated to studying the human immune system.
The new Institute will work directly with the University of Colorado Anschutz Medical Campus and other leading research organizations to understand the dynamic balancing act of the human immune system, how it senses friend from foe and what goes wrong when we're ill.
For the first time, researchers have identified that an immune cell subset called gamma delta T cells that may be causing and/or perpetuating the systemic inflammation found in normal aging in the general geriatric population and in HIV-infected people who are responding well to drugs (anti-retrovirals).
The ability to respond to injury is a biological process shared by organisms of different kingdoms that can even result in complete regeneration of a part or structure that was lost. Due to their immobility, multicellular fungi are prey to various predators and are therefore constantly exposed to mechanical damage.
Conventional combinatorial anticancer therapy has shown promising outcomes; still, a significant interest in developing new methods to reinforce and possibly merge chemotherapy and immunotherapy persists.
The realization that cellular metabolism dictates immune cell development, differentiation and function afford metabolic intervention as a potential venue for cancer immunotherapy. mTOR signaling, as a metabolic master regulator, controls immune cell biology in a cell type-specific and context-dependent manner.
Researchers from the UCLA Jonsson Comprehensive Cancer Center and the La Jolla Institute for Immunology have identified a new type of T cell called a phospholipid-reactive T cell that is able to recognize phospholipids, the molecules that help form cells' outer membranes.
In an update to a global clinical trial stretching from Philadelphia to four continents, the chimeric antigen receptor (CAR) T cell therapy Kymriah® (tisagenlecleucel, formerly CTL019) led to long-lasting remissions in patients with relapsed/refractory (r/r) diffuse large B-cell lymphoma (DLBCL).