All news from Immuno Haematology & Blood Transfusion

CRISPR Reveals New Immune System Regulators

Scientists have created the first retroviral CRISPR-Cas9 gene editing library to explore the regulation of mouse T cells, which are key cells in the immune system. Researchers from the Wellcome Sanger Institute and their collaborators have mapped the most important genes for controlling T helper cells and identified several new regulatory genes.

The Optimal Immune Therapeutic Strategies For Liver Cancer

AIST medical scientists have presented novel pathways involving T immune cell exhaustion, providing evidence and rationale for designing optimal strategies for immune checkpoint blockades in cancer patients. They succeeded in distinguishing the hepatocellular carcinoma group from the exhausted tumor-infiltrating immune cell composition of liver cancer patients.

Tuning Natural Killer Cell Anti-multiple Myeloma Reactivity

Natural killer (NK) cells are attractive candidates for allogeneic cell-based immunotherapy due to their potent antitumor effector function and good safety profile. NK cells express killer immunoglobulin-like receptors (KIRs) and the NKG2A receptor important for NK cells education as well as providing inhibitory signals upon encountering HLA-expressing target cells. Multiple myelomas (MM) is an example of a tumor expressing relatively high levels of HLA molecules.

Human Dendritic Cell ER Stress Response Reduces T cell Alloreactivity

Acute graft- vs. host disease (GVHD) is an important cause of morbidity and death after allogeneic hematopoietic cell transplantation (HCT). We identify a new approach to prevent GVHD that impairs monocyte-derived dendritic cell (moDC) alloactivation of T cells, yet preserves graft- vs.-leukemia (GVL). Exceeding endoplasmic reticulum (ER) capacity results in a spliced form of X-box binding protein-1 (XBP-1s).