Immune Hematology

Heat waves can reduce the body’s immune response to flu, according to new research in mice at the University of Tokyo. The results have implications for how climate change may affect the future of vaccinations and nutrition. Climate change is predicte to reduce crop yields and nutritional value, as well as widen the ranges of disease-spreading insects. However, the effects of heat waves on immunity to influenza had not been studied before.
University of Tokyo Associate Professor Takeshi Ichinohe and third-year doctoral student Miyu Moriyama investigated how high temperatures affect mice infected with influenza virus. “Flu is a winter-season disease. I think this is why no one else has studied how high temperatures affect flu,” said Ichinohe.

Influenza virus

The influenza virus survives better in dry, cold air, so it usually infects more people in winter. However, Ichinohe is interested in how the body responds after infection. The researchers housed healthy, young adult female mice at either refrigerator-cold temperature (4 degrees Celsius or 39.2 degrees Fahrenheit); room temperature (22 C or 71.6 F), or heat wave temperature (36 C or 96.8 F).

When infected with flu, the immune systems of mice in hot rooms did not respond effectively. Most affected by the high heat condition was a critical step between the immune system recognizing the influenza virus and mounting a specific, adaptive response. Otherwise; heat-exposed mice had no other significant changes to their immune system: They had normal reactions to flu vaccines injected under the skin. Moreover, bacteria living in the gut, which are increasingly becoming regarde as important for health; remained normal in the mice living in hot rooms.

Temperature and nutrition
Notably; mice exposed to high temperature ate less and lost 10 % of their body weight within 24 hours of moving to the hot rooms. Their weight stabilized by day two and then mice are infecting by breathing in live flu virus on their eighth day of exposure to heat.

Mice living in heat wave temperatures could mount a normal immune response if researchers provided supplemental nutrition before and after infection. Researchers gave mice either glucose (sugar) or short-chain fatty acids, chemicals naturally produced by intestinal bacteria.

surgically connected

In experiments at room temperature, researchers surgically connected mice so those body fluids moved freely between underfed and normally fed mice; both infected with influenza. The fluids from normally fed mice prompted the immune systems of underfed mice to respond normally to the flu virus.
“Does the immune system not respond to influenza virus maybe because the heat changes gene expression? Or maybe because the mice don’t have enough nutrients? We need to do more experiments to understand these details,” said Moriyama. The results may shed light on the unfortunate experience of getting sick again while recovering from another illness. “People often lose their appetite when they feel sick. If someone stops eating long enough to develop a nutritional deficit; that may weaken the immune system and increase the likelihood of getting sick again;” said Ichinohe.