A new systematic review provides a succinct summary of the scientific evidence for and/or against causal associations for 47 adverse events following immunization (AEFI). Findings from the study is present during the Pediatric Academic Societies (PAS) 2019 Meeting, taking place on April 24 – May 1 in Baltimore. “Health care providers desire objective and clear information on a broad range of vaccine safety issues to assist them in answering patient questions;” said Matthew Dudley, PhD, MSPH, one of the authors of the study.
Vaccine safety issues
“There have been no recent comprehensive reviews on AEFI, and previous reviews are not write for providers or the public. This systematic review provides an update to the scientific evidence assessing possible causal associations of AEFI compile in the 2012 report from the Institute of Medicine (IOM) and the 2014 report from the Agency for Healthcare Research and Quality (AHRQ); along with clear causality conclusions intend for health care providers.”
The review found that for 12 of the 47 AEFI studied, a causal relationship has been established with at least one vaccine currently routinely recommended to the general population in the U.S. These 12 confirmed adverse reactions are: anaphylaxis, arthralgia/arthritis (mild, acute and transient, not chronic), deltoid bursitis (when vaccine is administered improperly)
Confirmed adverse reactions
Disseminate varicella infection (in immune deficient individuals for whom the varicella vaccine is contraindicate), encephalitis, febrile seizures; Guillain-Barré Syndrome, hepatitis (in immune deficient individuals for whom the varicella vaccine is contraindicated), herpes zoster; immune thrombocytopenic purpura; meningitis and syncope. Most of these adverse reactions are rare.
For the other 35 AEFIs; the evidence does not support a causal relationship with vaccines recommended for routine use in the U.S. In particular; the evidence shows a clear lack of association between certain vaccines and AEFIs: influenza vaccines do not cause asthma; childhood vaccines do not cause autism; vaccines do not cause diabetes; vaccines given to immunocompetent persons do not cause hepatitis, influenza vaccines do not cause MS in adults; and DTP and hepatitis B vaccines do not cause Sudden Infant Death Syndrome (SIDS).
Dr. Dudley added, “Although vaccines currently recommended for the general population in the U.S. do cause some adverse reactions; vaccines have an excellent safety profile overall and provide protection against infectious diseases to individuals and the general population.”
As vaccine-preventable infectious diseases continue to decline; people have become increasingly concerned about the risks associated with vaccines. Furthermore; therefore technological advances and continuously increased knowledge about vaccines have led to investigations focused on the safety of existing vaccines which have sometimes created a climate of concern.
Adverse event following immunization is any untoward medical occurrence which follows immunization and which does not necessarily have a causal relationship with the usage of the vaccine. Because If not rapidly and effectively dealt with; can undermine confidence in a vaccine and ultimately have dramatic consequences for immunization coverage and disease incidence