Haematology

A prototype wearable device, tested in animal models, can continuously collect live cancer cells directly from a patient’s blood. Developed by a team of engineers and doctors at the University of Michigan; it could help doctors diagnose and treat cancer more effectively. “Nobody wants to have a biopsy. If we could get enough cancer cells from the blood, we could use them to learn about the tumor biology and direct care for the patients.

Methods of capturing cancer

That’s the excitement of why we’re doing this,” says Daniel F. Hayes, M.D., the Stuart B. Padnos Professor of Breast Cancer Research at the University of Michigan Rogel Cancer Center and senior author on the paper in Nature Communications. Tumors can release more than 1,000 cancer cells into the bloodstream in a single minute. Current methods of capturing cancer cells from blood rely on samples from the patient usually no more than a tablespoon taken in a single draw. Some blood draws come back with no cancer cells, even in patients with advanced cancer; and a typical sample contains no more than 10 cancer cells.

Over a couple of hours in the hospital, the new device could continuously capture cancer cells directly from the vein, screening much larger volumes of a patient’s blood. In animal tests; the cell-grabbing chip in the wearable device trapped 3.5 times as many cancer cells per milliliter of blood as it did running samples collected by blood draw.

Chemical engineering

“It’s the difference between having a security camera that takes a snapshot of a door every five minutes or takes a video. If an intruder enters between the snapshots; you wouldn’t know about it;” says Sunitha Nagrath, Ph.D., associate professor of chemical engineering at U-M; who led the development of the device.

Research shows that most cancer cells can’t survive in the bloodstream, but those that do are more likely to start a new tumor. Typically, it is these satellite tumors; called metastases; that are deadly, rather than the original tumor. This means; cancer cells captured from blood could provide better information for planning treatments than those from a conventional biopsy.

The team tested the device in dogs at the Colorado State University’s Flint Animal Cancer Center in collaboration with Douglas Thamm, VMD, a professor of veterinary oncology and director of clinical research there. They injected healthy adult animals with human cancer cells; which are eliminated by the dogs’ immune systems over the course of a few hours with no lasting effects.

Clinical research

For the first two hours post-injection, the dogs were given a mild sedative and connected to the device; which screened between 1-2 percent of their blood. At the same time; the dogs had blood drawn every 20 minutes; and the cancer cells in these samples were collected by a chip of the same design.
The device shrinks a machine that is typically the size of an oven down to something that could be worn on the wrist and connected to a vein in the arm. Because For help with the design; the engineering team turned to Laura Cooling, M.D., a professor of clinical pathology at U-M and associate director of the blood bank; where she manages the full-size systems.