The researches find that the New research suggests that intermittent fasting; cycling through periods of normal eating and fasting may regulate blood sugar (glucose) levels even when accompanied by little-to-no weight loss. The study is published ahead of print in the American Journal of Physiology- Regulatory, Integrative and Comparative Physiology. In people with mild obesity, intermittent fasting has been found effective for weight loss and an associated reduction of high blood pressure and cholesterol.

Regulate blood sugar levels

However; less is known about its effects on people who are extremely obese and whose obesity is caused more by genetics than by lifestyle. Researchers examined mice with genetic obesity and high insulin and glucose levels. These mice do not produce the appetite-regulating hormone leptin.  Previous research suggests that impaired leptin signaling can be a primary cause for obesity in humans. The obese mice followed an alternate day feeding schedule for two and a half weeks; with unlimited access to food on feeding days.

Neither a control group of lean mice following the same alternate day eating pattern nor the obese mice lost weight throughout the trial. However, on non-feeding days, “improvement [of glucose control] in both control and [obese] mice occurred in the absence of weight loss;” the researchers wrote.  The fact that blood glucose regulation improved only on non-feeding days; but occurred without significant weight loss, suggests that the benefits of intermittent fasting “likely vary considerably on a day-to-day basis,” the researchers said.

Significant weight loss

Normally, your pancreas releases insulin when your blood sugar; or “blood glucose,” gets high after a meal, for example. That signals your body to absorb glucose until levels get back to normal. But if you have diabetes; your body doesn’t make insulin (type 1 diabetes) or doesn’t respond to it normally (type 2 diabetes). That can leave your blood sugar too high for too long. Over time, that can damage nerves and blood vessels and lead to heart disease and other problems.

If you have diabetes, your doctor may ask you to keep track of your blood sugar by testing it at home with a special device called a blood glucose monitor or home blood sugar meter. It takes a small sample of blood, usually from the tip of your finger, and measures the amount of glucose in it. Your doctor will tell you when and how to test your blood sugar. Each time you do it; log it in a notebook or online tool or in an app. The time of day; recent activity, your last meal, and other things can all affect whether a reading will be of concern to your doctor. So try to log relevant information like: