Phenoxybenzamine and doxazosin pretreatments were equally effective in maintaining hemodynamic control during surgical resection of pheochromocytoma. Use of inotropic agents and norepinephrine did not differ significantly between groups.
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In a Phase 1 trial, patients with an advanced or aggressive form of systemic mastocytosis had rapid and durable responses with few adverse effects following treatment with an investigational drug, BLU-285 that targets the genetic mutation called KIT D816V found in more than 90% of the cases. The study was presented at the 59th American Society of Hematology (ASH) Annual Meeting and Exposition in Atlanta.
To target and eliminate colorectal cancer, a novel three-step system was developed by researchers using nuclear medicine. In this study, researchers achieved a 100% cure rate without any treatment-related toxic effects in a mouse model.