Acute leukemia develops quickly and worsens rapidly Leukemia is a cancer of the blood or bone marrow. Bone marrow produces blood cells. Leukemia can happen when there is a problem with the production of blood cells. It usually affects the leukocytes, or white blood cells. It is most likely to affect people over the age of 55…
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AICAr (5-amino-4-imidazolecarboxamide riboside; also called Acadesine) has been found to inhibit cell proliferation and has cytotoxic potential for childhood acute lymphoblastic leukemia (ALL) cells. Much of the drug’s cytotoxic mechanisms; however, remain unknown. A new study published in The FASEB Journalexplores the mechanisms behind AICAr. Specifically, the study was to determine; 1) whether AMP-activated protein kinase (AMPK) was…
Researchers have been struggling for years to find a treatment for patients who have a recurrence of acute myeloid leukemia (AML); an aggressive blood cancer that is one of the most lethal cancers. About 19,520 news cases are diagnosed a year; and about 10,670 people a year die from it, according to the American Cancer…
Many new anti-cancer drugs inhibit proteins that are essential for the proliferation of cancer cells. One example is ibrutinib, an innovative therapy for chronic lymphocytic leukemia first approved in 2014. Chronic lymphocytic leukemia, caused by uncontrolled growth of cells from the body’s immune system. It is the most common leukemia in the Western world. Most…
Acute T-cell lymphoblastic leukemia is a rare type of blood cancer that affects mostly children. This blood cancer appears from the precursor cells that produce T lymphocytes (a type of white blood cells)
For patients with rheumatoid arthritis (RA) who are positive for rheumatoid factor, anti-citrullinated protein antibodies (ACPA), or other risk factors, denosumab may be useful for inhibiting bone erosion, according to results published in Rheumatology.
Checking for minimal residual disease early in treatment can help some young high-risk leukemia patients avoid bone marrow transplantation without compromising their long-term survival Hospital investigator led the international retrospective analysis.
A team at Tokyo Medical and Dental University(TMDU) has revealed the molecule to cancer development, showing that the absence of the lead to dysregulation of the cell cycle, albeit with differing cancer-related outcomes.
Results from the largest study of hepatitis B and C and HIV infection prevalence in cancer patients show an alarmingly high rate of undiagnosed acute and chronic hepatitis B and C.
Hepatitis B and C are serious but treatable viral infections that cancer patients should know they have—because these viruses can cause life-threatening complications when certain cancer treatments are used.
The US Food and Drug Administration (FDA) has approved a new drug for the treatment of acute lymphoblastic leukemia (ALL), a cancer of the blood and bone marrow.
The agency has granted approval for calaspargase pegol-mknl (Asparlas, Servier Pharmaceuticals), an asparagine-specific enzyme, to be used as part of a multi-agent chemotherapeutic regimen in pediatric and young adult patients (age 1 month to 21 years).
A mechanism which drives leukemia cell growth has been discovered by researchers at the University of Sussex, who believe their findings could help to inform new strategies when it comes to treating cancer. Acute myeloid leukemia (AML) is a devastating blood cancer with around 3,000 new cases annually in the UK.