All news from Hematology & Oncology

Hematology

A Molecular Epigenetic Marker Predict Survival Of Children With Leukemia

“In the long term, I hope this can pave the way for new tailor-made treatments for leukemia and lymphoma in children,” says Zahra Haider, doctoral student at the Department of Medical Bio sciences at Umeå University. The most common type of cancer in children, acute lymphoblastic leukemia (ALL); as well as lymphoblastic lymphoma  are characterized…

Hematology

Antibody Containing Regimens For Acute Lymphoblastic Leukemia

The relapse rate remains high after chemotherapy for adult patients with acute lymphoblastic leukemia (ALL). With better molecular diagnosis and classification as well as better assessment for minimal residual disease; major progress in the treatment for refractory and/or relapse ALL is being made. In addition to the tyrosine kinase inhibitors (TKIs) for Philadelphia chromosome positive…

Hematology

Antibody Could Increase Cure Rate For Blood, Immune Disorders

An antibody-based treatment can gently and effectively eliminate diseased blood-forming stem cells in the bone marrow to prepare for the transplantation of healthy stem cells, according to a study in mice by researchers at the Stanford University School of Medicine. Because The researchers believe the treatment could circumvent the need to use harsh; potentially life-threatening…

Leukemia

Antibody Containing Regimens For Acute Lymphoblastic Leukemia

The relapse rate remains high after chemotherapy for adult patients with acute lymphoblastic leukemia (ALL). With better molecular diagnosis and classification as well as better assessment for minimal residual disease, major progress in the treatment for refractory and/or relapsed ALL is being made. In addition to the tyrosine kinase inhibitors  for Philadelphia chromosome-positive ALL, immunotherapeutic…

Hematology

Researchers Speed Up Detection Of Blood Infection

Researchers from The University of Western Australia have developed a new method of detecting blood infection that they hope will dramatically speed up diagnosis and treatment of severe infection. The research follows last year’s exciting results from a screening test to detect antibiotic resistance and ensure the right antibiotics can be prescribed quicker. Chemical characteristics…

Blood cancer

An Aggressive Leukemia: An Atlas of It

A team of researchers led by Bradley Bernstein at the Ludwig Center at Harvard has used single-cell technologies; and machine learning to create a detailed “atlas of cell states” for acute myeloid leukemia (AML); that could help improve treatment of the aggressive cancer. AML is characterized by the accumulation of white blood cells in the…

Leukemia treatment

New Therapy Discovered: For Aggressive Blood Cancer

Researchers at the Vetmeduni Vienna; and the Ludwig Boltzmann Institute for Cancer Research have identified a new therapeutic strategy for Acute Myeloid Leukemia (AML); the most common form of acute leukemia. However, they found that the activity of the mutated oncogenic protein C/EBPα; is dependent on a functional epigenetic helper; the MLL1 histone methyltransferase complex.…

Leukemia

Blood Clots In Cancer Patients: CASSINI Trial Publishes Data

The first clinical study investigating the use of the direct oral anticoagulant, rivaroxaban, to prevent blood clots in patients with cancer at high-risk published in the New England Journal of Medicine. The study found no significant reduction in venous thromboembolism or death in the overall 180-day trial period; however, the researchers did observe a lower…

Blood cancer

Leukemia Risk: Genetic Variations In Fourth Gene

St. Jude Children’s Research Hospital scientists have identified genetic variations in a fourth gene that are associated with an increased risk of acute lymphoblastic leukemia (ALL) in Hispanic children. The research appears in the journal Blood. The gene is ERG, a transcription factor that is also mutated in the leukemic cells of some ALL patients. In this…

Acute Myeloid Leukemia

The Treatment of Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells; characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cells. Symptoms may include feeling tired, shortness of breath, easy bruising and bleeding, and increased risk of infection. Occasionally, spread may occur to the brain, skin, or gums. As an acute leukemia, AML progresses rapidly and…

Leukemia

Protein CDK6 In Influencing Development Of MPN

MPNs are a group of rare, malignant diseases of the bone marrow involving the production of an excess of red blood cells; white blood cells and/or platelets. These are chronic diseases with only 1 to 2 new cases diagnosed per 100,000 people every year. MPNs can affect people at any age, but they are most…