Children with pediatric acute lymphoblastic leukemia (ALL) gain weight during treatment, and at St. Jude Children's Research Hospital have discovered that this problem begins with remission-induction treatment and suggests that early intervention should be considered.

Chemotherapy drugs to treat, one of which is an increased risk of becoming overweight or obese. And Patients are growing Because therapy can Also Affect Their height. Researchers studied 372 children with ALL and reviewed changes in their body mass index  (BMI), height and weight from diagnosis to five years off therapy.

The scientists' findings show that obesity was prevalent-and height growth , especially in patients with identified risk factors (age ≥10 years at diagnosis, standard / high-risk status, white blood cell count ≥ 50 × 109 / L at diagnosis, and positive central nervous system disease) was compromised.

"Once we found these increases in BMI over time ," said first author Emily Browne, DNP, RN, CPNP, director of the Transition Oncology Program at St. Jude. "If we could intervene, when should we?" The answer: As soon as possible.

"Over the whole population that was studied, we found statistically significant weight gain even during remission-induction therapy ," said corresponding author Hiroto Inaba, MD, Ph.D. member of the St. Jude Department of Oncology. "We saw a need for an intervention at that point."

To address weight gain, they strongly suggest early interventions. These interventions include parent and guardian education about proper diet and exercise, which encompass cutting down sugar intake and instituting some baseline activity level.

Growth hormone deficiency

For the issue of height, the researchers recommend evaluating certain patients for growth hormone deficiency . The results of this study appeared on October 16 in the scientific journal  Cancer .

"When you look at the literature of childhood obesity prevention for the general population, there are interventions that could also help ALL patients," Browne said. "But we need to adopt those recommendations to take the cancer therapy into account."

Here's the problem: Medications like glucocorticoids stimulate fat production and appetite. Also, cancer treatment can cause nausea, pain, and fatigue. Therefore, many patients are not eating healthfully or physically active during therapy.

These factors can lead to an increased risk of obesity, which can result in substantial physical and psychosocial morbidity and possible complications, high blood pressure, and bone health. Treatment also causes growth issues.

Younger children may be able to overcome this issue because they still grow after therapy is completed, but older children may suffer more because they are at a later stage of development which is compromised with therapy.