Haematology

Researches find that the cardiovascular system by orchestrating the control of blood flow to different parts of the body. Because The discovery; published in the Journal of Physiology, may pinpoint where cardiovascular issues such as high blood pressure and heart failure are controlled in the brain.global control of blood flow is the flow of blood in the cardiovascular system.

Blood pressure and heart failure

It is calculate by dividing the vascular resistance into the pressure gradient. Using genetically modified viruses in an animal model; therefore the researchers are able to make brain cells that govern blood flowglow under the microscope. This allow them to trace, for the first time; the cells’ connections to multiple parts of the cardiovascular system.

They identified one critical group of cells in the most evolutionarily ancient part of the brain; the medulla oblongata, that send connections to multiple cardiovascular targets; therefore suggesting a preeminent role for these cells. In a follow-up study the team rendered those same brain cells sensitive to laser light (a technique called ‘optogenetics’); allowing them to control their activity with the flick of a switch.

Genetically modified viruses

Brain cells are find to simultaneously exert influence on multiple regions of the body; including the heart and the blood vessels of the fore and hindlimbs, suggesting that the function of these cells is to coordinate activity across the cardiovascular system as a whole. Associate Professor Simon McMullan, who led the Macquarie University team; said the study reveals how the brain directs blood flow to different parts of the body; therefore a finding which has puzzled neuroscientists for many years.

“They find that brain cells broadcast their message to many different targets to co-ordinate global control of blood flow;” said Associate Professor McMullan.  Because “The brain’s control over your heart and blood vessels is essential for your survival. Even doing something as simple as going from lying down to a sitting up position can cause huge shifts in blood flow that, if left unchecked, could threaten your ability to stay conscious; and therefore, alive.”

Global control of blood flow

Professor Robin McAllen, who led the team from the Florey Institute of Neuroscience & Mental Health, said, “The body needs to orchestrate competing demands for blood from different tissues at different times. We have discovered master controllers of the cardiovascular system that regulate the heart and blood vessels at the same time.” high blood pressure, HTN or HPN, is a medical condition in which the blood pressure is chronically elevated. In current usage, the word “hypertension” without a qualifier normally refers to systemic, arterial hypertension.