The researches find that the blood test may one day predict if a newly diagnosed breast cancer patient will likely relapse years later, a City of Hope study suggests. Therefore “This is the first success linking a solid tumor with blood biomarkers an indicator of whether a patient will remain in remission;” said Peter P. Lee, M.D., chair of the Department of Immuno-Oncology at City of Hope and corresponding author of the study. “When patients are first diagnosed with cancer; it is important to identify those at higher risk for relapse for more aggressive treatments and monitoring.

The blood test may one day

Staging and new tests based on genomics analysis of the tumor are currently available for risk stratification. However; a predictive blood test would be even more attractive but is not yet available. Because They are trying to change the status quo.” The effectiveness of a person’s anti-tumor immune response is determine by the balance between pro-inflammatory and anti-inflammatory signaling pathways in response to cytokines; according to the July 8 Nature Immunology study.

Lee and his colleagues use data on 40 breast cancer patients who are follow for a median of four years. Results are validate in a separate cohort of 38 additional breast cancer patients to create a benchmark; that predicts if a breast cancer patient will likely relapse within a handful of years. The balance of cytokine signaling responses in “peripheral blood immune cells” the engine behind a healthy immune system; are indicators of the overall state of a person’s immune system, said Lee; the Billy and Audrey L. Wilder Professor in Cancer Immuno therapeutics at City of Hope.

Person’s immune system

“So, these findings may go beyond cancer to address other diseases the immune system must battle;” he added. “This general approach may also be useful for predicting outcomes in patients with autoimmune and infectious diseases.” A cancer patient’s peripheral blood immune cells’; a critical part of the immune system; tends to have decreased pro-inflammatory cytokine signaling responses and increased immune suppressive cytokine signaling responses, meaning a systemic immune environment is created that is conducive to the spread of cancer.

Lee and his colleagues analyzed signaling responses to many pro- and anti-inflammatory ;cytokines in different immune cell types that are found in peripheral blood from breast cancer patients who were newly diagnosed with the disease. They found altered signaling to four different cytokines (two pro- and two anti-inflammatory) in regulatory T cells in some patients. These cytokine signaling patterns in peripheral blood at diagnosis reflects the state of the immune system and predicts future relapse three to five years later.