General medicine

The study to find that diets high in soy foods are associate with a decreased risk of osteoporotic bone fractures in pre menopausal breast cancer survivors. Therefore Breast cancer is the second most common cancer among women in the United States; with 1 in 8 women diagnose with it during their lifetime. Because Many treatments for breast cancer cause premature menopause and decrease bone mineral density.

Osteoporotic bone fractures

This leads to a higher incidence of osteoporosis-relate fractures among survivors compare to healthy women in the same age range; and yet many factors connect to this increase in fracture risks are understudied. Because A fracture is the (local) separation of an object or material into two, or more; pieces under the action of stress.

The word fracture is often apply to bones of living creatures (that is, a bone fracture); or to crystals or crystalline materials, such as gemstones or metal. Sometimes; in crystalline materials, individual crystals fracture without the body actually separating into two or more pieces.

Individual crystals fracture

Researchers here studied the impact that BMI, exercise; and soy food consumption had on bone fracture rates among breast cancer survivors. The study used data from the Shanghai Breast Cancer Survival Study of 5,042 newly diagnosed breast cancer survivors between the ages of 20 and 75. Researchers collected detailed information at enrollment; including cancer diagnosis and treatment history, medication use, dietary habits, exercise and other lifestyle factors.

About 52% of women in the study were postmenopausal. Patients then had follow-up visits at 18 months, and 3, 5; and 10 years after their diagnosis to update exposure and outcome information. Throughout the 10-year study period, 3.6% of survivors reported an osteoporotic bone fracture.

Significantly reduced risk

Higher soy intake is associate with a 77% reduced risk of osteoporotic fractures in younger women; and exercise shows a significantly reduce risk of fractures among older women. Consistent with prior studies; the extend use of tamoxifen; a drug that is prescribed for breast cancer patients showed a 37% reduced risk of fractures in the overall study population. Tamoxifen is a selective estrogen receptor modulator, or SERM, that causes an increase in bone mineral density.

Soy based foods, which are rich in is oflavones, provide a natural SERM.”The menopausal transition is known to be a period of high risk for bone loss; and give the relative scarcity of data related to fracture risk among younger women with breast cancer, this study marks an important contribution to this body of literature;” said the paper’s lead author, Evelyn Hsieh. “Our findings, in particular regarding the protective effects of soy food consumption provide novel insight into how future interventions can be best tailor to different risk groups.”