In an observational study of patients who received ledipasvir and sofosbuvir treatment for HCV, it was found that contrary to guidelines, 8 and 12-week treatment regimens did not result in statistically significant differences in SVR12 in black patients.
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Pacritinib was significantly more effective than the best available therapy, including ruxolitinib, in reducing splenomegaly and trended toward a reduction in total symptom score in patients with myelofibrosis and thrombocytopenia.
Researcher assesses for prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD) place a greater emphasis on basing treatment decisions on trends in laboratory values rather than a single abnormal result. The Kidney Disease: Improving Global Outcomes (KDIGO) has been updated clinical practice guidelines. The study was published in the Annals of Internal Medicine.
A new study in the Journal of General Internal Medicine, published by Springer, shows that opioid prescribing has dropped after a peak in 2012. Lead author Katherine Hadlandsmyth in the US further noted that the decline was mostly due to decreases in long-term opioid prescribing, which carries a much greater risk for harmful side effects, addiction, and overdose, relative to short-term prescribing.
A new survey of sleeping subjects, published in The Journal of Clinical Endocrinology & Metabolism , reports untreated sleep apnea could elevate blood sugar and fat levels, stress hormones and blood pressure . Also, the study supports the reliable use of continuous positive airway pressure ( CPAP ), a machine that increases air pressure in the throat to keep the airway open during sleep .