In an observational study of patients who received ledipasvir and sofosbuvir treatment for HCV, it was found that contrary to guidelines, 8 and 12-week treatment regimens did not result in statistically significant differences in SVR12 in black patients.
Pacritinib was significantly more effective than the best available therapy, including ruxolitinib, in reducing splenomegaly and trended toward a reduction in total symptom score in patients with myelofibrosis and thrombocytopenia.
Researcher assesses for prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD) place a greater emphasis on basing treatment decisions on trends in laboratory values rather than a single abnormal result. The Kidney Disease: Improving Global Outcomes (KDIGO) has been updated clinical practice guidelines. The study was published in the Annals of Internal Medicine.
A new study in the Journal of General Internal Medicine, published by Springer, shows that opioid prescribing has dropped after a peak in 2012. Lead author Katherine Hadlandsmyth in the US further noted that the decline was mostly due to decreases in long-term opioid prescribing, which carries a much greater risk for harmful side effects, addiction, and overdose, relative to short-term prescribing.
A new survey of sleeping subjects, published in The Journal of Clinical Endocrinology & Metabolism , reports untreated sleep apnea could elevate blood sugar and fat levels, stress hormones and blood pressure . Also, the study supports the reliable use of continuous positive airway pressure ( CPAP ), a machine that increases air pressure in the throat to keep the airway open during sleep .