Gastroenterology

The researches find that the patients with inflammatory bowel disease (IBD) have increased risk of type 2 diabetes, according to a study published online Aug. 5 in Clinical Gastroenterology and Hepatology. Tine Jess, M.D., from the Bispebjerg and Frederiksberg Hospital in Copenhagen, Denmark; and colleagues conducted a nationwide population-based cohort study involving 6,028,844 persons in Denmark to examine the long-term risk of type 2 diabetes among patients with IBD. Data are compare for individuals with and without a diagnosis of IBD from 1977 through 2014.

Inflammatory bowel disease

Diabetes is a disease in which the body does not produce enough, or properly respond to, insulin; a hormone produced in the pancreas. Insulin is need to turn sugar and other food into energy. In diabetes, the body either doesn’t make enough insulin or can’t use its own insulin as well as it should; or both. This causes sugar to accumulate in the blood; often leading to various complications. The American Diabetes Association reported in 2009 that there are 23.6 million children and adults in the United States 7.8% of the population; who have diabetes.

While an estimated 17.9 million in the US alone have been diagnosed with diabetes, nearly one in four (5.7 million) diabetics are unaware that they have the disease. Many types of diabetes are recognized: The principal three are: The researchers found that 3,436 patients with IBD developed type 2 diabetes during 736,072 person-years of follow-up, compared with 2,224 expected cases (standardized incidence ratio [SIR], 1.54). The risk is significantly increase for patients with ulcerative colitis and those with Crohn disease (SIRs, 1.54 and 1.57, respectively); and for women and men (SIRs, 1.51 and 1.57, respectively).

Symptom of active disease

Ulcerative colitis (Colitis ulcerosa, UC) is a form of inflammatory bowel disease (IBD). Ulcerative colitis is a form of colitis, a disease of the intestine; specifically the large intestine or colon, that includes characteristic ulcers, or open sores; in the colon. The main symptom of active disease is usually constant diarrhea mix with blood; of gradual onset. Ulcerative colitis is, however, believe to have a systemic etiology that leads to many symptoms outside the intestine. Because of the name, IBD is often confuse with irritable bowel syndrome (“IBS”), a troublesome, but much less serious, condition.

Ulcerative colitis has similarities to Crohn’s disease, another form of IBD. The highest risk was seen in the first year after IBD diagnosis (SIR, 4.48), and risk remained elevated for 20 or more years after diagnosis (SIR, 1.26). Neither frequency of health care contacts nor corticosteroid exposure accounted for the increased risk. The risk of type 2 diabetes was significantly higher for patients who received a diagnosis of IBD from 2003 through 2014 versus those diagnosed from 1977 through 1988 or from 1989 through 2002 (SIRs, 1.79 versus 1.47 and 1.48, respectively).