gastroenterology

The study find that the A recent trial has now shown that nor-urso is also an effective treatment; option for nonalcoholic fatty liver disease. The results were recently published in leading journal “The Lancet Gastroenterology & Hepatology”. More than a quarter of the Austrian population suffers from a form of nonalcoholic fatty liver disease, usually caused by a poor lifestyle with too much fatty and sugary food and too little exercise, so that it also goes hand-in-hand with obesity. Between 35% and 50% of people in the 50 – 60 age-group already have a fatty liver.

Nonalcoholic fatty liver disease

Fatty liver disease is a so-call silent condition that is usually only discover by accident. However; the long-term consequences can be serious and can even lead to cirrhosis and cancer of the liver. Around 10 – 30% of all fatty liver diseases are classified as the most dangerous form of fatty liver steatohepatitis/NASH; which in turn develops into cirrhosis of the liver in 15 – 25% of cases. The Phase IIa trial of nor-urso that we have recently completed with help from numerous Austrian and German centres shows positive results when used in nonalcoholic fatty liver disease.”

Stefan Traussnigg, MedUni Vienna’s Department of Medicine III; lead author of the study   The main finding is as follows: synthetically produce bile acid “protects” the liver from inflammation, which could then culminate in fibrosis. The researchers use the hormone effect of the bile acid as a target. Trauner explains: The bile acid circulates through the body like a steroid hormone and regulates many metabolic processes. In fatty liver disease; it is as if a bile-acid-signal resistance develops; so that these processes no longer function properly. Nor-urso re-intensifies the hormone effect of the bile acid.”

The hormone effect

This gives patients a much better prognosis for the further course of the disease. The MedUni Vienna researchers now want to conduct further studies to test whether nor-urso also helps to inhibit the commonest causes of death in fatty liver disease, namely cardiovascular diseases such as heart attacks or strokes, thereby improving life expectancy in general. “It would be logical to expect that – and we are optimistic. But we have not yet verified it,” stresses Trauner.

At the same time, the hepatologists at MedUni Vienna, who are world leaders in the study of liver and biliary tract diseases, have developed two further therapy options using bile acid, which have already been prominently publicized. A further approach targets the activation of the bile acid receptor FXR (a sensor for bile acid). This receptor is involved in important processes such as regulation of lipid and glucose metabolism and the synthesis and circulation of bile acid. Thus, the long-term data from a Phase III trial on the use of obeticholic acid in primary biliary cholangitis (PBC), as the first clinically available FXR ligand, were published this year. Says Trauner: