Poo transplant or "Faecal microbiota transplantation" (FMT) can successfully treat patients with ulcerative colitis, new research from the University of Adelaide shows. Researchers found a short duration of low intensity FMT using anaerobically.
The randomized, double-blind study published in the journal JAMA was a collaboration between the University of Adelaide, South Australian Health and Medical Research Institute (SAHMRI), CSIRO and CALHN (SA Health).
It involved 73 adults with mild to moderately active ulcerative colitis, an inflammatory bowel disease which affects the lining of the large intestine and rectum, causing symptoms including pain, bloody stools and an increased risk of colon cancer. Patients received either pooled donor FMT that had been anaerobically or their own stool as placebo via colonoscopy followed by two enemas.
Researchers found a short duration of low-intensity FMT using anaerobically (in an oxygen-free environment) prepared pooled donor FMT could induce remission in ulcerative colitis, with a 32% rate of remission compared to 9% with placebo.
This is a similar treatment result to the best currently available therapies. Many of the currently available therapies for ulcerative colitis improve the disease by suppressing the immune system which can lead to potential side effects like infection or malignancy.
The Most Important Difference in the Trial
The most important difference in this trial is the use of anaerobic (oxygen-free) stool processing, "says study leader Dr. Sam Costello, Gastroenterologist, The Queen Elizabeth Hospital and Lecturer, University of Adelaide's Medical School. oxygen and we know that with anaerobic stool processing a large number of donor bacteria survive so that they can be administered to the patient.
"They believe that this was the reason that we had a good therapeutic effect with only a small number of treatments." An agreement has already been reached with the company Macrobiotic to commercialize the development of a microbial therapeutic from the study.
Their long-term aim is to develop rationally designed microbial therapies that can replace FMT, '' said Dr. Costello. "These will have bacteria in a pill that can carry out the therapeutic effect without the need to take whole feces.