Stem cells transformed into the 3-D human liver tissue by scientists from the Medical Research Council (MRC) Centre for Regenerative Medicine at the University of Edinburgh show promising support of liver function when implanted into mice with a liver disease.
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Problems like obesity and alcoholism appear to chronically trigger in the liver a receptor known to amplify inflammation in response to invaders like bacteria, scientists report.
According to a study, researchers examined women who undergo menopausal hormone therapy appear to have a higher risk of developing microscopic colitis. The study was published in Gastroenterology. They used data from the Nurses’ Health Study (NHS) and NHSII that have documented reproductive and menopausal factors biennially dating back to 1988 and 1989, respectively.
Researchers from many international institutions have teamed up to design a more effective drug for liver cancer therapy. Their compound may help improve survival rates and reduce adverse effects. Hepatocellular carcinoma, or primary liver cancer, tend to grow and expand at a fast rate.
If it is not caught early, this means that people who have been diagnosed with it may not survive longer than 11 months. Recent studies show that in the United States, hepatocellular carcinoma is the ninth leading cause of cancer-related deaths. The study was published in the journal PNAS.
The US Food and Drug Administration (FDA) has approved lenvatinib capsules (Lenvima, Eisai) for first-line treatment of patients with unresectable hepatocellular carcinoma (HCC). The kinase inhibitor has previously been approved for differentiated thyroid cancer and renal cell cancer.
A study shows that patients suffering sudden liver failure could in the future benefit from a new treatment that could reduce the need for transplants. Acute Liver Failure occurs when a healthy liver is so seriously damaged it can no longer regrow and recover, leaving patients in urgent need of a transplant.
The liver helps support almost every other organ, by removing toxins, as well as making and storing the proteins and energy sources the body requires. Often the damaged liver can regrow and recover on its own, but when it suffers massive injury, regeneration may fail and even 24 hours without a fully working liver can be life-threatening.
By genetically manipulating and removing the most common mutant form of the p53 gene that promotes colorectal cancer in humans, an international team of scientists demonstrated that this therapy reduces tumor growth and tissue invasion.
A study published in the Journal of Bone and Mineral Research shows that the risk of fractures increases by about 30% after a gastric bypass operation. It was also discovered that falls increase after these operations.
Little information is available on the effectiveness of organized colorectal cancer (CRC) screening on screening uptake, incidence, and mortality in community-based populations.
The rarity of appendix cancer, accounting for less than 1% of tumors that originate in the gastrointestinal tract, and the lack of scientific data for this disease means the current treatment guidelines recommend applying therapies to people with appendix cancer.
New study calls for human-based tools to unravel the pathogenesis of non-alcoholic steatohepatitis (NASH). The contribution of in silico, in vitro and pathways-based systems biology approaches to unraveling the pathogenesis of this disease are described, and how this human-relevant research can be used for anti-NASH drug development.