The researches find that the Obesity seems to be associated with increased odds of pediatric multiple sclerosis (MS), according to a study published online in JAMA Neurology. Brenda Huppke, M.D., from the University Medical Center Göttingen in Germany; and colleagues examined the correlation of obesity with pediatric MS risk and first-line therapy response in a retrospective study.
The Obesity treatment
A total of 453 patients with relapsing-remitting pediatric MS and a body mass index measurement taken within six months of diagnosis are include in the study. The researchers find that 126 patients (27.8%) were overweight or obese at diagnosis; and obesity is associate with statistically significantly increase odds of MS in girls and boys (odds ratios, 2.19 and 2.14, respectively).
Compared with non overweight patients; obese patients had statistically significantly more relapses on first-line treatment with interferon beta and glatiramer acetate (annualized relapse rate, 1.29 versus 0.72) and a higher rate of second-line treatment (56.8 versus 38.7% ). “The findings do not indicate that obesity promotes greater disease activity; but pharmacokinetic factors are more likely associate with treatment response;” the authors write.
Non overweight patients
Obesity is a leading preventable cause of death worldwide, with increasing prevalence in adults and children; and authorities view it as one of the most serious public health problems of the 21st century. Obesity is stigmatize in the modern Western world; though it has been perceive as a symbol of wealth and fertility at other times in history; and still is in many parts of Africa.
Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have an adverse effect on health; leading to reduced life expectancy. Body mass index (BMI); which compares weight and height, is used to define a person as overweight (pre-obese) when their BMI is between 25 kg/m2 and 30 kg/m2 and obese when it is greater than 30 kg/m2.
Breathing difficulties during sleep
Obesity is associate with many diseases, particularly heart disease, type 2 diabetes; breathing difficulties during sleep; certain types of cancer; and osteoarthritis. Obesity is most commonly cause by a combination of excessive dietary calories; lack of physical activity, and genetic susceptibility, though a limited number of cases are due solely to genetics; medical reasons or psychiatric illness.
The primary treatment for obesity is dieting and physical exercise. If this fails; anti-obesity drugs may be take to reduce appetite or inhibit fat absorption. In severe cases, surgery is perform or an intragastric balloon is place to reduce stomach volume and or bowel length, leading to earlier satiation and reduce ability to absorb nutrients from food.
“This suggestion may have relevant management implications given that a healthy weight may potentially optimize treatment outcomes and reduce disease-related burden and health care costs.” Several authors disclosed financial ties to the pharmaceutical industry.