Gastroenterology

The researches find that the patients with atrial fibrillation (AF), the efficacy and safety of edoxaban versus warfarin is not altered with a history of liver disease, according to a study published in the July 16 issue of the Journal of the American College of Cardiology. Arman Qamar, M.D., M.P.H., from Brigham and Women’s Hospital and Harvard Medical School in Boston; and colleagues compared edoxaban with warfarin in 21,105 patients with AF followed for 2.8 years (5.1%with a history of liver disease).

Patients with atrial fibrillation

Primary efficacy and safety end points are assess and stratified by history of liver disease. Liver disease (also called hepatic disease) is a broad term describing any single number of diseases affecting the liver. Many are accompanied by jaundice cause by increase levels of bilirubin in the system. The bilirubin results from the breakup of the hemoglobin of dead red blood cells; normally, the liver removes bilirubin from the blood and excretes it through bile.

A patient is any person who receives medical attention, care, or treatment. The person is most often ill or injure and in need of treatment by a physician or other medical professional; although one who is visiting a physician for a routine check-up may also be viewed as a patient. The researchers find that the adjust risks for stroke or systemic embolic event (SSEE) are similar for patients without versus with liver disease (adjust hazard ratio, 0.90; 95% confidence interval [CI], 0.67 to 1.22); but patients with liver disease more often had major bleeding (adjusted hazard ratio, 1.38; 95 percent CI, 1.10 to 1.74).

Receives medical attention

Pharmacokinetic/pharmacodynamic assessment of edoxaban did not differ significantly for patients with versus without liver disease. For higher-dose edoxaban versus warfarin, the HRs for SSEE were 0.86 (95% CI, 0.73 to 1.01) and 1.11 (95% CI, 0.54 to 2.30) in patients without and with liver disease, respectively; for major bleeding, the corresponding HRs were 0.80 (95% CI, 0.70 to 0.91) and 0.91 (95% CI, 0.56 to 1.47). The liver is the largest solid organ in the body; and is also consider a gland because among its many functions, it makes and secretes bile. The liver is located in the upper right portion of the abdomen protect by the rib cage.

It has two main lobes that are made up of tiny lobules. The liver cells have two different sources of blood supply. The hepatic artery supplies oxygen rich blood that is pump from the heart, while the portal vein supplies nutrients from the intestine and the spleen. Normally, veins return blood from the body to the heart, but the portal vein allows nutrients and chemicals from the digestive tract to enter the liver for processing and filtering prior to entering the general circulation.