Gastroenterology

Researcher find that liver disease in animal models. In a new study, the first of its kind; therefore researchers at the University of California San Diego School of Medicine report an association between the herbicide and negative effects upon the human liver. Fatty liver disease is also referr to as Nonalcoholic Fatty Liver Disease (NAFLD) or Nonalcoholic Steatohepatitis (NASH).

Herbicide and negative effects

This is a group of conditions where there is accumulation of excess fat deposits over the liver. This fat deposit is also see among alcoholics. Because In a study published in Clinical Gastroenterology and Hepatology; a team led by Paul J. Mills, PhD, professor and chief in the Department of Family Medicine and Public Health at UC San Diego School of Medicine; examined glyphosate excretion in the urine samples of two patient groups those with a diagnosis of NASH (non-alcoholic steatohepatitis; a type of nonalcoholic fatty liver disease or NAFLD), and those without.

The results, they found, are significant: Regardless of age; race, body mass index (BMI); ethnicity or diabetes status, glyphosate residue was significantly higher in patients with NASH than it was in patients with a healthier liver. The findings, coupled with prior animal studies; said Mills, suggest a link between the use of commercial glyphosate in our food supply, which has increased significantly over the past 25 years; and the prevalence of NAFLD in the United States; which too has been on the rise for two decades.

Use of commercial glyphosate

The study examined urine samples of 93 patients. Forty-one percent were male; 42% were white or Caucasian; 35%were Hispanic or Latino. Average BMI was 31.8. Patients are originally recruited as part of a larger study at the UC San Diego NAFLD Research Center conduct between 2012 and 2018. Liver biopsies are use to determine the presence or absence of NAFLD while classifying the subjects by cohort.

Mills plans to next put a group of patients on an all-organic diet and track them over the course of several months; examining how a herbicide-free diet might affect biomarkers of liver disease. Glyphosate is the most widely use herbicide in the United States; it was developed and patented by agrochemical giant Monsanto in the 1970s and its sales represent approximately 50 percent of the company’s annual revenue.

Biomarkers of liver disease.

“The increasing levels [of glyphosate] in people’s urine very much correlates to the consumption of Roundup treated crops into our diet,” said Mills. But while researchers say this study shows a link between herbicide exposure and liver disease in human subjects, Mills said much work remains to be done.”There are so many synthetic chemicals we are regularly expose to,” he says. “We measured just one.”