Cannabis; Only a few studies have look into the use of cannabinoids for hearing loss, tinnitus, or balance disorders, suggesting the need for further research. Some of the latest articles in the U.S. National Library of Medicine include the study by Tabrizi, et al., who report the potential of endocannabinoids to inhibit the action of a receptor (TRPV1) that responds to noxious stimuli, causing pain and injury to the cell. The plant is also known as hemp, although this term is often used to refer only to varieties of Cannabis cultivated for non-drug use
The TRPV1 receptor activation is consider responsible for the pathology development of cystitis, asthma, epilepsy, diabetes, and hearing loss. The use of antagonists, including CBD; so to target this receptor may have a clinically therapeutic potential. Fiskerstrand and colleagues identify a gene mutation that produces; which an error in endocannabinoid metabolism; which result in a multifocal debilitating neuro degenerative disease.
Central nervous systems
PHARC affects the peripheral and central nervous systems; which causing impaire vision and hearing loss. The gene mutation disrupts the metabolism of endocannabinoids; reducing the cells that remove damage cells and infection; while dysregulating neurogenesis. In tinnitus research, Smith and Zheng investigate if cannabinoid receptor activation; which could create a pro or anti epileptic action in the cochlear nucleus and if cannabis could make tinnitus better or worse. The results of this research were inconclusive.
The use of antineoplastic drugs, particularly cisplatin; which has show to result in hearing loss. Ghosh, et al., evaluated the use of endocannabinoids deliver via transtympanic administration to rats that were subsequently injected with cisplatin. The results “support the role of the endocannabinoid/CB2R system in maintaining normal hearing in the rat cochlea.” The authors conclude that the use of transtympanic injections of agonists to the CB2 receptor provide effective protection against cisplatin induce hearing loss.
Benefits of cannabis
Acoustic trauma is an area that is widely research. The formation of free radicals and reduced blood flow are key players in the cochlea. It has also show that tinnitus has a central representation and that antiepileptic drugs are sometime used as a treatment. Zheng, Reid, and Smith investigated whether THC and CBD deliver to rats could provide relief from tinnitus.
Their findings suggest that cannabinoids may increase the occurrence of tinnitus in noise-exposed rats; especially when there is prior hearing damage. In hearing care, further investigation into the benefits of cannabis is need; so particularly in the treatment of debilitating tinnitus and hyperacusis with comorbid sleep deprivation and psychopathology.