A five-minute scan of blood vessels in the neck during mid-life could predict cognitive decline ten years before symptoms appear, claims new UCL research funded by the British Heart Foundation (BHF). The findings were presented at the AHA Scientific Sessions conference in Chicago.
Factors like aging and high blood pressure cause stiffening of these blood vessels, diminishing their protective effect. As a result, a progressively stronger physical 'pulse' can travel deep into the fragile vessels which supply the brain.
Over time, this can cause damage to the small vessels of the brain, structural changes in the brain's blood vessel networks and minor bleeds were known as mini-strokes, all of which may contribute to the development of dementia.
An international team of researchers, led by Professor John Deanfield (UCL Institute of Cardiovascular Science), studied a group of 3,191 middle-aged volunteers who were given an ultrasound measuring the intensity of the pulse reaching their brain. Over the next 15 years, researchers monitored the participant's memory and problem-solving ability.
Participants whose blood reached their brain with the highest intensity (top 25%) at the beginning of the study were at around 50% higher risk of developing cognitive decline over the next decade compared to the rest of the participants. This difference was present even after adjustments for possible confounding factors, such as age, BMI, blood pressure, diabetes, and whether participants had other heart conditions.
Cognitive decline is a noticeable and measurable decline in cognitive abilities including memory, language, thinking and judgment skills. It is often one of the first signs of dementia, but not everyone who shows signs of cognitive decline will go on to develop dementia.
Next, the researchers plan to use MRI scans to check if these individuals also display structural and functional changes within the brain which may explain the changes in memory and thinking. They also plan to test whether the scan improves the existing predictive 'risk scores' for dementia.
Dr. Scott Chiesa (UCL Institute of Cardiovascular Science) said: "These findings demonstrate the first direct link between the heart's pulse and the brain and future impairments in cognitive function. It is a potentially treatable cause of cognitive decline in middle-aged adults which can be spotted well in advance of any noticeable changes in brain structure or function."
Dementia affects around 850,000 people in the UK. Vascular dementia is one of the most common types of dementia, caused by a problem with blood supply to the brain which damages or kills brain cells. Research suggests that controlling blood pressure and cholesterol, having a healthy diet, regular exercise and not smoking can all help to stave off dementia.
Professor Metin Avkiran, Associate Medical Director at the British Heart Foundation, said: "The best way to protect yourself is to lead to a lifestyle that keeps your blood vessels healthy. Are linked to heart diseases such as high blood pressure and lack of exercise are strongly linked to dementia. It is a case of a healthy body and healthy mind. "